Association between histology grade, expression of HsMCM2, and cyclin A in human invasive breast carcinomas

Bukholm, I.R.K.; Bukholm, G.; Holm, R.; Nesland, J.M.
May 2003
Journal of Clinical Pathology;May2003, Vol. 56 Issue 5, p368
Academic Journal
Aim: Increased proliferation of tumour cells has prognostic value in human invasive breast carcinomas (IBCs), and high histology grade and cyclin A expression, which may reflect high proliferation rate, are associated with poor prognosis. Expression of HsMCM2 is related to cell proliferation. This study evaluates the correlation between the expression of cyclins A, D1, D3, and E, Ki-67, proliferating cell nuclear antigen (PCNA), histology grade, and HsMCM2 expression, in addition to the independent prognostic value of HsMCM2 expression in human IBCs. Methods: Immunohistochemistry to evaluate HsMCM2, Ki-67, and PCNA expression in tumours from 147 patients with IBC. Results: Nuclear staining for HsMCM2 was seen in 10-30% of the tumour cells in 30 samples, in 30-70% in 40 samples, in >70% in 44 samples, and in <10% in 33 samples. One way ANOVA showed a significant association between expression of HsMCM2 and cyclin A, D3, E, histology grade, and Ki-67. A borderline correlation was seen between HsMCM2 and PCNA. In multivariate analysis, the only association was with cyclin A, in addition to a borderline association with histology grade. In a Cox regression hazards model, expression of HsMCM2 was associated with poor patient survival, although it lost its independent prognostic value when cyclin A expression was included. Ki-67 and PCNA expression were not associated with patient survival. Conclusion: Cyclin A expression is independently associated with HsMCM2 expression, histology grade, and Ki-67. HsMCM2 expression is associated with poor patient survival, although it loses prognostic value when adjusted for cyclin A.


Related Articles

  • HMGN5: a potential oncogene in gliomas. Qu, Jintao; Yan, Runmin; Chen, Juxiang; Xu, Tao; Zhou, Jingxu; Wang, Mei; Chen, Chao; Yan, Yong; Lu, Yicheng // Journal of Neuro-Oncology;Sep2011, Vol. 104 Issue 3, p729 

    Gliomas are the most common primary brain tumors in the central nervous system and a leading cause of tumor-related death. High-mobility group nucleosome binding domain 5 ( HMGN5/NSBP1), which is highly expressed in breast cancer and in hormone-induced mouse uterine adenocarcinoma, acts as a...

  • Reasons for breast cancer heterogeneity.  // Journal of Biology;2008, Vol. 7, p67 

    Breast cancers differ in many ways, such as in their cell of origin, the molecular alterations causing them and the susceptibility and defenses of the patient, and this makes it difficult to give the most appropriate treatment. Two recent papers have contributed to the establishment of a more...

  • Breast cancer: Breast cancer classification. Alderton, Gemma K. // Nature Reviews Cancer;Mar2014, Vol. 14 Issue 3, p155 

    The article discusses the classification of breast cancer tumours using normal breast cells and breast epithelial markers.

  • How retinoids regulate breast cancer cell proliferation and apoptosis. Simeone, A.-M.; Tari, A. M. // Cellular & Molecular Life Sciences;Jun2004, Vol. 61 Issue 12, p1475 

    Breast cancer still remains a major problem in its incidence, morbidity and mortality; therefore, more effective strategies for its prevention are urgently needed. Retinoids, natural and synthetic derivatives of vitamin A, possess antiproliferative and proapoptotic properties, making them a...

  • Targeting AMP-activated protein kinase in adipocytes to modulate obesity-related adipokine production associated with insulin resistance and breast cancer cell proliferation.  // Diabetology & Metabolic Syndrome;2011, Vol. 3 Issue 1, p16 

    The article focuses on the study of antigenic membrane protein (AMP)kinase in adipocytes to modulate adipokine production related to insulin resistance and breast cancer cell proliferation. It states that metformin helps in improving the imbalance related to lipopolysaccharide (LPS)-induced...

  • Involvement of chemokine receptors in breast cancer metastasis. Muller, Anja; Homey, Bernhard; Soto, Hortensia; Nianfeng Ge; Catron, Daniel; Buchanan, Matthew E.; McClanahan, Terri; Murphy, Erin; Wei Yuan; Wagner, Stephan N.; Barrera, Jose Luis; Mohar, Alejandro; Verastegui, Emma; Zlotnik, Albert // Nature;3/1/2001, Vol. 410 Issue 6824, p50 

    Reports that the chemokine receptors CXCR4 and CCR7 are highly expressed in human breast cancer cells, malignant breast tumors and metastases. Mediation of actin polymerization and pseudopodia formation with induction of chemotactic and invasive responses in breast cancer cells; Finding that in...

  • ANTICANCER EFFECT OF SAPINDUS TRIFOLIATUS ON HUMAN BREAST CANCER CELL LINES. Pradhan, D.; Joshi, V.; Tripathy, G. // International Journal of Pharma & Bio Sciences;Jan-Mar2010, Vol. 1 Issue 1, p1 

    Evaluation of anticancer effect of Sapindus trifoliatus (family- Sapindaceae) which has long been prescribed for various infectious and malignant diseases. Bio-assays of extracts from Sapindus trifoliatus showed that a fraction (fraction 3) from an ethanolic extract had an antiproliferative...

  • Syncytin is involved in breast cancer-endothelial cell fusions. Bjerregaard, B.; Holck, S.; Christensen, I. J.; Larsson, L.-I. // Cellular & Molecular Life Sciences;Aug2006, Vol. 63 Issue 16, p1906 

    Cancer cells can fuse spontaneously with normal host cells, including endothelial cells, and such fusions may strongly modulate the biological behaviour of tumors. However, the underlying mechanisms are unknown. We now show that human breast cancer cell lines and 63 out of 165 (38%) breast...

  • Signaling pathway switch in breast cancer. Guille, Arnaud; Chaffanet, Max; Birnbaum, Daniel // Cancer Cell International;2013, Vol. 13 Issue 1, p1 

    Next generation sequencing studies have drawn the general landscape of breast cancers and identified hundreds of new, actual therapeutic targets. Two major signaling pathways seem to be altered in a vast proportion of breast cancers. The PI3 kinase/AKT pathway is activated and the JUN/MAPK...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics