TITLE

Diabetes, pancreatic cancer, and metformin therapy

AUTHOR(S)
Jun Gong; Robbins, Lori A.; Lugea, Aurelia; Waldron, Richard T.; Jeon, Christie Y.; Pandol, Stephen J.
PUB. DATE
November 2014
SOURCE
Frontiers in Physiology;Nov2014, Vol. 5, p1
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Pancreatic cancer carries a poor prognosis as most patients present with advanced disease and preferred chemotherapy regimens offer only modest effects on survival. Risk factors include smoking, obesity, heavy alcohol, and chronic pancreatitis. Pancreatic cancer has a complex relationship with diabetes, as diabetes can be both a risk factor for pancreatic cancer and a result of pancreatic cancer. Insulin, insulin-like growth factor-1 (IGF-1), and certain hormones play an important role in promoting neoplasia in diabetics. Metformin appears to reduce risk for pancreatic cancer and improve survival in diabetics with pancreatic cancer primarily by decreasing insulin/IGF signaling, disrupting mitochondrial respiration, and inhibiting the mammalian target of rapamycin (mTOR) pathway. Other potential anti-tumorigenic effects of metformin include the ability to downregulate specificity protein transcription factors and associated genes, alter microRNAs, decrease cancer stem cell proliferation, and reduce DNA damage and inflammation. Here, we review the most recent knowledge on risk factors and treatment of pancreatic cancer and the relationship between diabetes, pancreatic cancer, and metformin as a potential therapy.
ACCESSION #
100604750

 

Related Articles

  • New listings on Australian PBS.  // PharmacoEconomics & Outcomes News;Jan2014, Issue 694, p9 

    The article reports that patients with diabetes will receive alogliptin/metformin through the Pharmaceutical Benefits Scheme (PBS) of the Australian government starting February 1, 2014.

  • Metformin may protect against intrahepatic cholangiocarcinoma in diabetes.  // Endocrine Today;Jan2013, Vol. 11 Issue 1, p18 

    The article reports on a study which found that patients with diabetes who received metformin were at reduced risk for intrahepatic cholangiocarcinoma, whereas biliary tract disease, cirrhosis, diabetes and smoking increased that risk.

  • UTSTAT.  // Urology Times;Aug2013, Vol. 41 Issue 9, p11 

    Statistics are presented on the percentage of mortality risk for prostate cancer every six months of use of metformin.

  • Diabetes treatment, prevention research shows promise. Coopman, Robert // Chain Drug Review;11/23/2015, Vol. 37 Issue 19, p26 

    The article reports on the progress of diabetes research as they pertain to the efficacy of metformin for treating cardiovascular disease in patients with or without diabetes and the possibility of islet cell transplantation and regeneration.

  • Metformin Use Correlates with Reduced Risk of Gallstones in Diabetic Patients: A 12-Year Follow-up Study. Kuan-Fu Liao; Hsun-Yang Chuang; Shih-Wei Lai // Frontiers in Pharmacology;10/24/2017, p1 

    Objective: Few studies are available on the association between gallstones and metformin use. The objective of the study was to determine whether metformin use is associated with gallstones. Methods: A population-based retrospective cohort study was conducted using the database of the Taiwan...

  • Link between Diabetes and Pancreatic Cancer.  // Australasian Science;Jun2014, Vol. 35 Issue 5, p11 

    The article focuses on the time-dependent link between being diagnosed with diabetes and pancreatic cancer, which was discovered by a study by Dr. Mehrdad Nikfarjam of the University of Melbourne and found that risk of pancreatic cancer was greater after diagnosis of diabetes.

  • Common diabetes drug linked to vitamin deficiency.  // Romanian Journal of Medical Practice;2010, Vol. 5 Issue 2, p87 

    The article reports on the findings of a study by Dutch scientists led by Coen Stehouwer of Maastrict University Medical Center which suggest that regular checking of vitamin B-12 levels during long-term metformin treatment for diabetes should be considered to prevent deficiency and its effects.

  • Renal Risks Lower with Metformin Use.  // Renal & Urology News;Feb2012, Vol. 11 Issue 2, p22 

    The article reports on the health effects of the use of metformin as first-time treatment for patients with type 2 diabetes.

  • Scant evidence on metformin's effectiveness in type 2 diabetes. Perry, Thomas L. // BMJ: British Medical Journal;5/23/2015, Vol. 350 Issue 8009, ph2650 

    A letter to the editor in response to the article "Using Metformin in the Presence of Renal Disease" in a 2015 issue is presented.

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics