Seroprevalence of Scrub typhus at a tertiary care hospital in Andhra Pradesh

Ramyasree, A.; Kalawat, U.; Rani, N. D.; Chaudhury, A.
January 2015
Indian Journal of Medical Microbiology;Jan2015, Vol. 33 Issue 1, p68
Academic Journal
Introduction: Scrub typhus is a rickettsial infection which is caused by Orientia tsutsugamushi and transmitted by the bite of the chigger of a mite. Delay in diagnosis can be fatal otherwise the treatment is simple, doxycycline being the drug of choice. Indirect immunoflurescence is considered gold standard but it is not used in India as it is costly and also not available. There is need for rapid, economic and simple test for the diagnosis of scrub typhus. This study was taken up to study the seroprevalence of scrub typhus in Andhra Pradesh and to compare two commonly used serological methods; rapid test and IgM ELISA. Materials and methods: This is a prospective study in which 100 serum samples from clinically suspected cases collected over a period of 3 months were processed for the detection of IgM antibodies for scrub typhus by ELISA and Rapid test. Samples were also tested for leptospirosis and dengue fever which the other common causes of fever prevalent in this region. Results: Total number of samples processed was 100 of which 52 were males and 48 females. Among the hundred samples 39 were seropositive. Positivity was higher in the age group of patients between 16 and 30 yrs of age. There was 97% correlation between ELISA and rapid method. Of the 100 samples only three samples positive by ELISA were negative by rapid method. Fever was the most common manifestation and there was no eschar and no mortality reported. Conclusion: Scrub typhus should be included in the differential diagnosis of fever of unknown origin along with dengue, malaria and leptospirosis which are the other common endemic infections in this part of the country.


Related Articles

  • Empirical treatment with doxycycline may treat non-malarial fevers in Laos.  // Infectious Disease News;Aug2013, Vol. 26 Issue 8, p36 

    The article reports on a study that treatment with doxycycline was found to be an effective approach to patients with fever such as scrub typhus and leptospirosis but not for malaria or dengue in Laos, that references a research by Paul Newton and colleagues from the Lao Oxford Mahosot Hospital...

  • Scrub Typhus Seroprevalence in Healthy Indian Population. Sengupta, Mallika; Anandan, Shalini; Daniel, Dolly; Jude Prakash, John Antony // Journal of Clinical & Diagnostic Research;Oct2015, Vol. 9 Issue 10, p1 

    Scrub typhus, a zoonosis caused by Orientia tsutsugamushi, is an important cause of acute febrile illness in India. This preliminary study determines the seroprevalence of scrub typhus in healthy Indian adults by measuring IgM and IgG antibodies to scrub typhus by ELISA in 100 healthy blood...

  • Differential diagnosis of scrub typhus meningitis from bacterial meningitis using clinical and laboratory features. Varghese, George M.; Mathew, Anoop; Kumar, Sudhir; Abraham, Oriapadickal Cherian; Trowbridge, Paul; Mathai, Elizabeth // Neurology India;Sep/Oct2013, Vol. 61 Issue 5, p17 

    Background: Central nervous system (CNS) involvement in the form of meningitis or meningoencephalitis is common in scrub typhus. As specific laboratory methods remain inadequate or inaccessible in developing countries, prompt diagnosis is often difficult. Aim: To identify the clinical and...

  • Clinical Profile Of Patients With Leptospirosis In A Tertiary Care Centre In North Kerala. Mohan, Mithun C.; Sudeep, K.; Karunakaran, Usha; Abdullah, Mariya; Shibu, Joseph; Nair, Haritha; Mukundan, Mukesh // Nepal Journal of Epidemiology;2014, Vol. 4 Issue 2, p7 

    An abstract of the article "Clinical Profile Of Patients With Leptospirosis In A Tertiary Care Centre In North Kerala," by Mithun C. Mohan and colleagues is presented.

  • Seroprevalence of brucellosis in Western Rajasthan: A study from a tertiary care centre. Bansal, Yashik; Aggarwal, Alisha; Gadepalli, Ravisekhar; Nag, Vijaya Lakshmi // Indian Journal of Medical Microbiology;Jul-Sep2019, Vol. 37 Issue 3, p426 

    Brucellosis is a significant bacterial zoonotic disease with a high seroprevalence in low-to-middle-income countries where there is a significant contact of humans with animals. This prospective study was conducted to observe the seroprevalence of brucellosis in 75 symptomatic patients with...

  • Clinical Profile of Scrub Typhus Patients in a Tertiary Care Hospital in Kerala. Chellamma, Prabhakumari; Paramasivam, Selvam; Thayyil, Jayakrishnan; Durairaj, Sivakumar // Indian Journal of Public Health Research & Development;Oct-Dec2016, Vol. 7 Issue 4, p330 

    Introduction: Scrub typhus is one of the reemerging Rickettsial diseases in India. The disease is spread to people by the bite of a mite infected with larval trombiculid mite. The objective of this study was to study the clinical profile and outcome of Scrub Typhus patients. Since scrub typhus...

  • Human Spotted Fever Group Rickettsioses Are Underappreciated in Southern Taiwan, Particularly for the Species Closely-Related to Rickettsia felis. Lai, Chung-Hsu; Chang, Lin-Li; Lin, Jiun-Nong; Tsai, Kun-Hsien; Hung, Ya-Chien; Kuo, Li-Li; Lin, Hsi-Hsun; Chen, Yen-Hsu // PLoS ONE;Apr2014, Vol. 9 Issue 4, p1 

    Background: Despite increased identification of spotted fever group rickettsioses (SFGR) in animals and arthropods, human SFGR are poorly characterized in Taiwan. Methods: Patients with suspected Q fever, scrub typhus, murine typhus, leptospirosis, and dengue fever from April 2004 to December...

  • Outbreak of scrub typhus in North India: a re-emerging epidemic. Sethi, Sunil; Prasad, Amber; Biswal, Manisha; Hallur, Vinay Kumar; Mewara, Abhishek; Gupta, Navneet; Galhotra, Shipra; Singh, Gagandeep; Sharma, Kusum // Tropical Doctor;Jul2014, Vol. 44 Issue 3, p156 

    Scrub typhus is re-emerging in India. We describe an outbreak of 45 cases from our tertiary care center in north India. This outbreak included city dwellers who had no history of travel to hilly areas. The classical feature of scrub typhus, the eschar, was also noted rarely in these patients....

  • Seroprevalence and Evaluation of Rapid Immunochromatographic Test and ELISA for the Detection of NS1 Antigen, IgM and IgG Antibodies for Early Diagnosis of Dengue Infection in a Tertiary Care Hospital, South India. P., Ronnimol; Takpere, Aparna Y.; Shahapur, Praveen R.; Parandekar, Prashant K. // Indian Journal of Public Health Research & Development;Jul-Sep2016, Vol. 7 Issue 3, p204 

    Dengue is one of the rapidly emerging global threats. In situations of epidemics and routine cases, early diagnosis is the key to successful management of dengue cases. There are many diagnostic kits available commercially, but their validity is unknown. The standard test is ELISA. In the...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics