Effectiveness of Estriol-Containing Vaginal Pessaries and Nitrofurantoin Macrocrystal Therapy in the Prevention of Recurrent Urinary Tract Infection in Postmenopausal Women

Raz, R.; Colodner, R.; Rohana, Y.; Battino, S.; Rottensterich, E.; Wasser, I.; Stamm, W.
June 2003
Clinical Infectious Diseases;6/1/2003, Vol. 36 Issue 11, p1362
Academic Journal
We compared the efficacy and safety of estriol-containing vaginal pessary use with those of oral nitrofurantoin macrocrystal (NM) therapy for preventing urinary tract infection (UTI) in postmenopausal women with recurrent UTI. Over a period of 9 months, 86 women received an estriol-containing vaginal pessary (0.5 mg estriol) twice weekly, and 85 women received NM (100 mg) once daily. We recorded 124 episodes of UTI in women who received estriol-releasing pessaries and 48 episodes of UTI in women treated with NM (P = .0003). Twenty-eight women (32.6%) who received estriol had no episodes of UTI versus 41 women (48.2%) in the NM group. There was a significant increase in the number of superficial cells in women who received estriol, whereas in the NM group, no such changes occurred. However, there was no change in the extent of Lactobacillus colonization and in the vaginal pH in women who received estriol. Use of an estriol-containing pessary is less effective than oral NM therapy in the prevention of bacteriuria in postmenopausal women because of its failure to restore the population of lactobacilli and to reduce the vaginal pH in these women.


Related Articles

  • Bye-Bye, UTIs. Minkin, Mary Jane; Hanlon, Toby // Prevention;Jul2002, Vol. 54 Issue 7, p164 

    Offers tips on how to prevent repeat urinary tract infections.

  • UTI breakthrough. Howard, Beth // Shape;Feb98, Vol. 17 Issue 6, p22 

    Focuses on prevention medicines for urinary tract infections. Insight on cystitis; Identification of vaccines.

  • Preventing a urinary tract infection. Young, Stephanie // Glamour;Feb95, Vol. 93 Issue 2, p30 

    Offers information on preventing urinary tract infections. Symptoms; Importance of hygiene; Prevention of bacteria build-up by drinking large quantities of fluids; Soaps to be used; Urination after sex.

  • Preventing urinary-tract infections. Verespej, Michael A. // Industry Week/IW;7/3/95, Vol. 244 Issue 13, p35 

    Offers several tips for preventing urinary-tract infections. Drinking lots of fluids; Taking showers.

  • Carbohydrate Receptor Depletion as an Antimicrobial Strategy for Prevention of Urinary Tract Infection. Svensson, Majlis; Frendeus, Bjorn; Svanborg, Catharina; Platt, Frances; Butters, Terry; Dwek, Raymond // Journal of Infectious Diseases;3/2/2001 Supplement 1, Vol. 183, pS70 

    Presents information on a study which evaluated the effects of glycosphingolipids depletion on bacterial adhesion, cell activation and in vivo infection. Efficacy of N-butyldeoxynojirimycin drug; Materials and methods; Results and discussion.

  • When you gotta go …. Weaks, Kevin // Southern Illinois Labor Tribune;8/2/2012, Vol. 75 Issue 52, p9 

    The article offers information on causal factors, symptoms and prevention of urinary bladder infections.

  • Headlines & Your Health.  // Cleveland Clinic Men's Health Advisor;Feb2013, Vol. 15 Issue 2, p5 

    The article focuses on a study published in the December 3, 2012 issue of the journal "Archives of Internal Medicine" which shows that taking antibiotics for a long time in treating male urinary tract infections (UTIs) is not good for reducing repeat urinary infections.

  • Are Cranberry Products Effective for the Prevention of Urinary Tract Infections? CAYLEY JR., WILLIAM E. // American Family Physician;12/1/2013, Vol. 88 Issue 11, p745 

    The article provides an answer to a question of whether cranberry products should be recommended for the prevention of urinary tract infections (UTI).

  • Prospects for a UTI vaccine: An update from the experts.  // Urology Times;Oct2011, Vol. 39 Issue 11, p8 

    A blog from an audio excerpt of doctor Klumpp and Uehling explaining the complexity of treatment of recurrent urinary tract infections due to increasing antibiotic resistance is discussed.


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics