Clearance of 14-3-3 Protein from Cerebrospinal Fluid Heralds the Resolution of Bacterial Meningitis

Bonora, Stefano; Zanusso, Gianluigi; Raiteri, Riccardo; Monaco, Salvatore; Rossati, Antonella; Ferrari, Sergio; Boffito, Marta; Audagnotto, Sabrina; Sinicco, Alessandro; Rizzuto, Nicola; Concia, Ercole; Di Perri, Giovanni
June 2003
Clinical Infectious Diseases;6/1/2003, Vol. 36 Issue 11, p1492
Academic Journal
The 14-3-3 protein, a cerebrospinal fluid (CSF) marker of neuronal damage that was recently adopted for the diagnosis of Creutzfeldt-Jakob disease, is also found in the CSF of patients with a variety of neurological disorders. We prospectively studied 12 consecutive patients with purulent bacterial meningitis and found that 14-3-3 protein was detected in all patients at admission to the hospital. All patients who recovered cleared 14-3-3 protein from the CSF before discharge from the hospital (this was the first CSF marker to clear), whereas those who died never cleared the protein.


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