TITLE

Isolated Antibody to Hepatitis B Core Antigen in Human Immunodeficiency Virus Type-1--Infected Individuals

AUTHOR(S)
Gandhi, Rajesh T.; Wurcel, Alysse; Hang Lee; McGovern, Barbara; Boczanowski, Melinda; Gerwin, Roslyn; Corcoran, Colleen P.; Szczepiorkowski, Zbingniew; Toner, Sarah; Cohen, Daniel E.; Sax, Paul E.; Ukomadu, Chinweike
PUB. DATE
June 2003
SOURCE
Clinical Infectious Diseases;6/15/2003, Vol. 36 Issue 12, p1602
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
We screened 651 human immunodeficiency virus (HIV)-1-infected subjects for hepatitis B surface antigen (HBsAg) and antibody to hepatitis B surface antigen (anti-HBs). Of a total of 387 subjects who tested negative for both HBsAg and anti-HBs, 142 underwent further testing for isolated presence of antibody to hepatitis B core antigen (anti-HBc). Of these 142 subjects, 60 (42%) tested positive for anti-HBc (isolated anti-HBc). Individuals coinfected with HIV-1 and hepatitis C virus (HCV) were more likely to have isolated anti-HBc than were subjects with HIV-1 alone (80% vs. 16%, respectively). Our findings suggest that individuals with HIV-1/HCV coin-fection for whom there is no serological evidence for hepatitis B virus when screened with HBsAg and anti-HBs will be positive for anti-HBc in >75% of cases. A screening strategy that tests only for HBsAg and anti-HBs in HIV-1-infected patients will miss a large number of individuals with isolated anti-HBc.
ACCESSION #
10024062

 

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