Severe Hepatotoxicity Associated with Rifampin-Pyrazinamide Preventative Therapy Requiring Transplantation in an Individual at Low Risk for Hepatotoxicity

Kunimoto, D.; Warman, A.; Beckon, A.; Doering, D.; Melenka, L.
June 2003
Clinical Infectious Diseases;6/15/2003, Vol. 36 Issue 12, pe158
Academic Journal
We report a case of severe hepatotoxicity associated with rifampin-pyrazinamide preventative therapy that required liver transplantation in a closely monitored, human immu-nodeficiency virus-uninfected individual who had no risk for hepatotoxicity. Because hepatotoxicity associated with this treatment appears to be idiosyncratic, we recommend closer monitoring of liver enzyme levels than do the Centers for Disease Control and Prevention guidelines, as well as at least temporary interruption of treatment during any elevation of liver enzyme levels greater than the normal value.


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