Monocyte and Lymphocyte Apoptosis Resistance in Acute and Chronic Brucellosis and Its Possible Implications in Clinical Management

Tolomeo, M.; Di Carlo, P.; Abbadessa, V.; Titone, L.; Barbusca, E.; Cannizzo, G.; Mancuso, S.; Arista, S.; Scarlata, F.
June 2003
Clinical Infectious Diseases;6/15/2003, Vol. 36 Issue 12, p1533
Academic Journal
This study evaluated the level of susceptibility of monocytes and lymphocytes to spontaneously induced and CH11-induced apoptosis in 16 patients with Brucella infection. The expression of some immunological and apoptotic markers was evaluated. Before therapy, monocytes showed a high level of resistance to spontaneously induced or CH11-induced apoptosis in all patients. In patients with acute infection, this resistance persisted for 10-20 days after treatment was initiated, then decreased; in chronically infected patients, it persisted after 45 days of treatment. Lymphocytes were also more resistant to CH11-induced apoptosis. The level of activated CD8[SUP+] T lymphocytes was high in patients with acute infection. The data indicate that the CD95-mediated apoptotic pathway is not involved in CH11 resistance. Lymphocytes are not infected by Brucella, so their resistance to apoptosis may be due to a soluble factor released by infected monocytes. The evaluation of levels of susceptibility to CH11-induced apoptosis in monocytes may be used to test the effectiveness of the therapy.


Related Articles

  • Apoptosis of lymphocytes and monocytes infected with influenza virus might be the mechanism of combating virus and causing secondary infection by influenza. Dongxu Xie; Hai Bai; Lihua Liu; Xiangyu Xie; Ayello, Janet; Xiaohui Ma; Junying Zhang // International Immunology;Nov2009, Vol. 21 Issue 11, p1251 

    Influenza affects most of the world's population annually, often causing a secondary infection, but pathological mechanisms of influenza virus infection remain unclear. We have found that influenza viruses have a selective preference for infecting monocytes and mature immune effector cells. This...

  • Microvesicular Caspase-1 Mediates Lymphocyte Apoptosis in Sepsis. Exline, Matthew C.; Justiniano, Steven; Hollyfield, Jennifer L.; Berhe, Freweine; Besecker, Beth Y.; Das, Srabani; Wewers, Mark D.; Sarkar, Anasuya // PLoS ONE;Mar2014, Vol. 9 Issue 3, p1 

    Objective: Immune dysregulation during sepsis is poorly understood, however, lymphocyte apoptosis has been shown to correlate with poor outcomes in septic patients. The inflammasome, a molecular complex which includes caspase-1, is essential to the innate immune response to infection and also...

  • β[sub2]-Microglobulin modified with advanced glycation end products delays monocyte apoptosis. Fan Fan Hou; Miyata, Toshio; Boyce, Joshua; Qian Yuan; Chertow, Glenn M.; Kay, Jonathan; Schmidt, Ann Marie; Owen Jr., William F. // Kidney International;Mar2001, Vol. 59 Issue 3, p990 

    Examines the effect of advance glycation end products (AGE-beta2m) on apoptosis and phenotype of human monocytes. Blocking of human AGE receptor; Chemical nature of AGE; Duration of AGE-beta2m effect on apoptosis.

  • Butyric acid induces apoptosis in both human monocytes and lymphocytes equivalently. Abe, Kazumasa // Journal of Oral Science;Mar2012, Vol. 54 Issue 1, p7 

    Short-chain fatty acids (SCFAs) are metabolites from anaerobic periodontopathic bacteria that induce apoptosis in immune cells such as lymphocytes, monocytes and macrophages. However, it remains unclear if SCFAs from pathogens induce apoptosis in monocytes/macrophages similarly with lymphocytes....

  • The lymphocyte-monocyte ratio in clinical practice. Balta, Sevket; Demırer, Zafer; Aparci, Mustafa; Yildirim, Ali Osman; Ozturk, Cengiz // Journal of Clinical Pathology;Jan2016, Vol. 69 Issue 1, p88 

    A letter to the editor is presented in response to the article "Pretreatment lymphocyte-monocyte ratio (LMR) as a potential prognostic factor in a cohort of patients with upper tract urothelial carcinoma."

  • Granzyme A: the road less traveled. Pinkoski, Michael J.; Green, Douglas R. // Nature Immunology;Feb2003, Vol. 4 Issue 2, p106 

    Cellular parasites have evolved clever antiapoptosis strategies to avoid being killed by CTLs. However, CTL release of granzyme A inactivates a key repair enzyme, Ape I, ensuring death of infected cells.

  • Dialysis fluids and monocytes: Suicide or murder? Cohen, J. John // Kidney International;Jul1998, Vol. 54 Issue 1, p283 

    Editorial. Investigates the effects of peritoneal dialysis solutions on cellular functions. Selection of blood monocytes for resident peritoneal macrophages; Incubation of monocytes in the solution; Distinction between necrosis and apoptosis.

  • Effect of light on white blood cell count in carp Cyprinus carpio L. Ruchin, A. B. // Biology Bulletin;Sep2006, Vol. 33 Issue 5, p517 

    In the dark, the lymphocyte count decreased while the monocyte and basophil counts increased in the carp blood. Conversely, the lymphocyte count increased and the monocyte and basophil counts decreased during 12D:12L, 16D:8L, and 0D:24L dark/light cycles, which can be considered as an...

  • Dietary modulation of the mucosal immune response to a parasite. McClure, Susan J. // Immunology & Cell Biology;Feb2009, Vol. 87 Issue 2, p159 

    This study investigated the hypothesis that dietary deficiency of readily available carbohydrate (raCHO) modifies the immune response of lambs to the gastrointestinal nematode Trichostrongylus colubriformis. Sixty helminthologically naive Merino lambs were fed throughout the experiment diets...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics