TITLE

Monocyte and Lymphocyte Apoptosis Resistance in Acute and Chronic Brucellosis and Its Possible Implications in Clinical Management

AUTHOR(S)
Tolomeo, M.; Di Carlo, P.; Abbadessa, V.; Titone, L.; Barbusca, E.; Cannizzo, G.; Mancuso, S.; Arista, S.; Scarlata, F.
PUB. DATE
June 2003
SOURCE
Clinical Infectious Diseases;6/15/2003, Vol. 36 Issue 12, p1533
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
This study evaluated the level of susceptibility of monocytes and lymphocytes to spontaneously induced and CH11-induced apoptosis in 16 patients with Brucella infection. The expression of some immunological and apoptotic markers was evaluated. Before therapy, monocytes showed a high level of resistance to spontaneously induced or CH11-induced apoptosis in all patients. In patients with acute infection, this resistance persisted for 10-20 days after treatment was initiated, then decreased; in chronically infected patients, it persisted after 45 days of treatment. Lymphocytes were also more resistant to CH11-induced apoptosis. The level of activated CD8[SUP+] T lymphocytes was high in patients with acute infection. The data indicate that the CD95-mediated apoptotic pathway is not involved in CH11 resistance. Lymphocytes are not infected by Brucella, so their resistance to apoptosis may be due to a soluble factor released by infected monocytes. The evaluation of levels of susceptibility to CH11-induced apoptosis in monocytes may be used to test the effectiveness of the therapy.
ACCESSION #
10024034

 

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