TITLE

EFFECTS OF PHOTOTHERAPY ON SERUM PARAOXONASE ACTIVITY AND TOTAL ANTIOXIDANT CAPACITY IN NEWBORN JAUNDICE

AUTHOR(S)
Kurban, Sevil; Annagür, Ali; Altunhan, Hüseyin; Mehmetoğlu, İdris; Örs, Rahmi; Erdem, Said Sami; Yerlikaya, Fatma Hümeyra; Toker, Aysun; Taşyürek, Erkan
PUB. DATE
September 2014
SOURCE
Nobel Medicus Journal;Sep-Dec2014, Vol. 10 Issue 3, p48
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Objective: Phototherapy is an efficient and commonly used form of therapy for the treatment of neonatal hyperbilirubinemia. Paraoxonase 1 (PONI) is an antioxidative enzyme, which eliminates lipid peroxides. The aim of our study was to investigate the effect of phototherapy on serum PON1 activity and total antioxidant capacity (TAC) in hyperbilirubinemic full-term newborns. Material and Method: The study was performed on 40-full-term newborns between 3 to 15 days of age exposed to phototherapy. Serum PON1 activity and TAC levels of the babies were determined before and after plwtothempy by spectrophotomeüic assays. Results: We have found that PON1 activity was not significantly affected by phototherapy whereas TAC levels were decreased significantly after phototherapy (p<0.001). Conclusion: Our findings demonstrated that phototherapy has no direct effect on PON1 activity. Also, decreased TAC levels might have resulted from increased oxidative stress which may lead to consumption of antioxidant molecules.
ACCESSION #
100108118

 

Related Articles

  • Bilirubin Rebound After Intensive Phototherapy for Neonatal Jaundice. BANSAL, ANURADHA; JAIN, SUKSHAM; PARMAR, VEENA R.; CHAWLA, DEEPAK // Indian Pediatrics;Jul2010, Vol. 47 Issue 7, p607 

    This study was conducted to determine the incidence and magnitude of postphototherapy bilirubin rebound in neonates. Subjects included inborn neonates needing phototherapy for hyperbilirubinemia. Standard guidelines were used to start and stop phototherapy. Rebound bilirubin was measured 24±6...

  • Efficacy of Oral Zinc Sulfate Intake in Prevention of Neonatal Jaundice. Maamouri, Gholamali; Boskabadi, Hassan; Mafinejad, Shahin; Bozorgnia, Yasaman; Khakshur, Ali // Iranian Journal of Neonatology;2014, Vol. 5 Issue 1, p11 

    Introduction: Jaundice is considered as a common clinical condition during infancy. Prevention of severe hyperbilirubinemia (jaundice) is safer and easier than current therapies, like phototherapy or blood exchange. In some animal studies, zinc was found effective in reducing jaundice. In this...

  • The side effects of phototherapy for neonatal jaundice: what do we know? What should we do? Xiong, Tao; Qu, Yi; Cambier, Stephanie; Mu, Dezhi // European Journal of Pediatrics;Oct2011, Vol. 170 Issue 10, p1247 

    Neonatal phototherapy (NNPT), a noninvasive, easily available therapy, has been widely used for the treatment of neonatal jaundice for more than half a century. Its efficiency in decreasing plasma bilirubin concentration is well documented, and NNPT leads to greatly reduced exchange transfusion...

  • Phototherapy for Neonatal Nonhemolytic Hyperbilirubinemia. Lazar, Leora; Litwin, Aviva; Merlob, Paul // Clinical Pediatrics;May1993, Vol. 32 Issue 5, p264 

    Phototherapy, an effective treatment for neonatal indirect hyperbilirubinemia, has guidelines for its initiation but none for its discontinuation. In our study, phototherapy was begun at a mean age of 90 hours in 28 full-term and 30 preterm infants with indirect nonhemolytic hyperbilirubinemia....

  • Hyperbilirubinemia guideline adherence in Russia illustrates universal challenges. Agulnik, Asya; Ryumina, Irina I.; Burgos, Anthony E. // European Journal of Pediatrics;Oct2009, Vol. 168 Issue 10, p1175 

    Guidelines for management of newborn hyperbilirubinemia have existed in Russia for many years. We sought to determine the degree to which management of hyperbilirubinemia in Russia meets three existing clinical protocols. We performed a cross-sectional chart review in a government-run, academic...

  • Bilirubin Screening in Newborns: What Should We Do? GANIATS, THEODORE G. // American Family Physician;8/15/2010, Vol. 82 Issue 4, p336 

    The author comments on articles on universal bilirubin screening in newborn infants in a 2009 issue of "Pediatrics." They include a U.S. Preventive Services Task Force report on the benefits and harms of phototherapy and two commentaries that call for a predischarge risk assessment for severe...

  • Clofibrate for unconjugated hyperbilirubinemia in neonates: A systematic review. Xiong, Tao; Chen, Dapeng; Duan, Zhoujin; Qu, Yi; Mu, Dezhi // Indian Pediatrics;Jan2012, Vol. 49 Issue 1, p35 

    Objective: To evaluate the effect of clofibrate for unconjugated hyperbilirubinemia in neonates. Methods: A systematic review with meta-analysis of randomized controlled trials or quasi-randomized controlled trials was conducted to evaluate the clofibrate treatment in neonates with unconjugated...

  • Urinary tract infection and indirect hyperbilirubinemia in newborns. Omar, Chamdine; Hamza, Shadi; Bassem, Abou Merhi; Mariam, Rajab // North American Journal of Medical Sciences;Dec2011, Vol. 3 Issue 12, p544 

    Background: Jaundice is a common problem during the neonatal period. About 60% of the full term and 80% of premature infants develop jaundice. It can be associated with serious illnesses such as Urinary tract infections. Aims: The aim of this study is to evaluate the incidence and prevalence of...

  • Comparison of the efficacy of Clofibrate with Phenobarbital in decreasing neonatal hyperbilirubinemia. Ahadi, A.; Mirzarahimi, M.; Ahmadabadi, F.; Tavasoli, A.; Parvaneh, N. // Iranian Journal of Neonatology;Autumn2013, Vol. 4 Issue 3, p13 

    Background: Hyperbilirubinemia is a common problem in newborn infants. It can progress to kernicterus in severe forms, unless an intervention is initiated. The objective of this study was to compare the efficacy of Clofibrate with Phenobarbital in full-term neonates with nonhemolytic jaundice....

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics