TITLE

The TCR's sensitivity to self peptide-MHC dictates the ability of naive CD8+ T cells to respond to foreign antigens

AUTHOR(S)
Fulton, Ross B; Hamilton, Sara E; Xing, Yan; Best, J Adam; Goldrath, Ananda W; Hogquist, Kristin A; Jameson, Stephen C
PUB. DATE
January 2015
SOURCE
Nature Immunology;Jan2015, Vol. 16 Issue 1, p107
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The strength with which complexes of self peptide and major histocompatibility complex (MHC) proteins are recognized by the T cell antigen receptor (TCR) dictates the homeostasis of naive CD8+ T cells, but its effect on reactivity to foreign antigens is controversial. As expression of the negative regulator CD5 correlates with self-recognition, we studied CD5lo and CD5hi naive CD8+ T cells. Gene-expression characteristics suggested CD5hi cells were better poised for reactivity and differentiation than were CD5lo cells, and we found that the CD5hi pool also exhibited more efficient clonal recruitment and expansion, as well as enhanced reactivity to inflammatory cues, during the recognition of foreign antigen. However, the recognition of complexes of foreign peptide and MHC was similar for both subsets. Thus, CD8+ T cells with higher self-reactivity dominate the immune response to foreign antigens, with implications for T cell repertoire diversity and autoimmunity.
ACCESSION #
100030866

 

Related Articles

  • The yin and yang of CD1d recognition. Adams, Erin J; Luoma, Adrienne M // Nature Immunology;Sep2012, Vol. 13 Issue 9, p814 

    No abstract available.

  • Individual MHCI-restricted T-cell receptors are characterized by a unique peptide recognition signature. Wooldridge, Linda // Frontiers in Immunology;Jul2013, Vol. 4, p1 

    Effective immunity requires that a limited TCR repertoire is able to recognize a vast number of foreign peptide-MHCI (peptide-major histocompatibility complex class I) molecules.This challenge is overcome by the ability of individual TCRs to recognize large numbers of peptides. Recently, it was...

  • Type II natural killer T cells use features of both innate-like and conventional T cells to recognize sulfatide self antigens. Girardi, Enrico; Maricic, Igor; Wang, Jing; Mac, Thien-Thi; Iyer, Pooja; Kumar, Vipin; Zajonc, Dirk M // Nature Immunology;Sep2012, Vol. 13 Issue 9, p851 

    Glycolipids presented by the major histocompatibility complex (MHC) class I homolog CD1d are recognized by natural killer T cells (NKT cells) characterized by either a semi-invariant T cell antigen receptor (TCR) repertoire (type I NKT cells or iNKT cells) or a relatively variable TCR repertoire...

  • Prospects and Limitations of T Cell Receptor Gene Therapy. Jorritsma, Annelies; Schotte, Remko; Coccoris, Miriam; de Witte, Moniek A.; Schumacher, Ton N. M. // Current Gene Therapy;Aug2011, Vol. 11 Issue 4, p276 

    No abstract available.

  • T cell receptor bias for MHC: co-evolution or co-receptors? Rangarajan, Sneha; Mariuzza, Roy // Cellular & Molecular Life Sciences;Aug2014, Vol. 71 Issue 16, p3059 

    In contrast to antibodies, which recognize antigens in native form, αβ T cell receptors (TCRs) only recognize antigens as peptide fragments bound to MHC molecules, a feature known as MHC restriction. The mechanism by which MHC restriction is imposed on the TCR repertoire is an unsolved...

  • Self-gratification yields not-so-naive T cells. Martin, Christopher E; Surh, Charles D // Nature Immunology;Mar2014, Vol. 15 Issue 3, p217 

    No abstract available.

  • A Critical Role of Nonclassical MHC in Tumor Immune Evasion in the Amphibian Xenopus Model. Haynes-Gilmore, Nikesha; Banach, Maureen; Edholm, Eva Stina; Lord, Edith; Robert, Jacques // Carcinogenesis;Aug2014, Vol. 35 Issue 8, p1 

    Nonclassical class Ib (class Ib) genes are found in all jawed vertebrates, including the amphibian Xenopus, which possesses at least 20 distinct Xenopus nonclassical class Ib genes (XNCs). As an immune evasion strategy, tumors often down-regulate surface expression of classical MHC class Ia...

  • TCR tuning. Dempsey, Laurie A. // Nature Immunology;Jun2012, Vol. 13 Issue 6, p533 

    No abstract available.

  • A primer on TCR signaling.  // Nature Immunology;Sep2014, Vol. 15 Issue 9, p789 

    No abstract available.

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics