Estimation of serum C-reactive protein levels and its correlation with HPV in patients with potentially malignant disorders and oral squamous cell carcinoma

Banga, Akanksha; Gulati, Nikita; Bhattacharya, Maumita; Kaur, Navneet; Shetty, Devi Charan; Hussain, Showket
November 2014
Journal of Oral & Maxillofacial Pathology (0973029X);2014 Special Issue, Vol. 18, pS48
Academic Journal
Background: Oral squamous cell carcinoma (OSCC) among all cancers is the major cause of morbidity and mortality in India. This can be attributed to lack of awareness among common population related to oral cancers. Apart from tobacco, other risk factors like human papillomavirus (HPV) have been associated with it. The development of a serum biomarker panel for early detection and disease monitoring is, therefore, warranted. C-reactive protein (CRP) has been shown to be associated with tumor invasion, lymph node metastasis, staging and survival in patients with OSCC. Aims: The purpose of the present study was to analyze the relationship between preoperative levels of CRP and presence of HPV in oral potentially malignant disorders (OPMD) and OSCC to predict their aggressiveness. Materials and Methods: Thirty histopathologically-confirmed cases of OPMDs, OSCC and an equal number of controls from North Indian population were analyzed for HPV infection and CRP expression by polymerase chain reaction (PCR) and enzyme-linked immunosorbent assay (ELISA), respectively. Results: On analysis of level of CRP, significantly higher level of CRP in OPMDs and OSCC compared to controls was observed. Significant differences in levels of CRP were also observed among OPMD and OSCC cases showing positivity for HPV, having higher levels of CRP. Conclusion: The present study demonstrates that elevated CRP is an independent prognostic factor inOSCC. CRP level, therefore, has significant potential as a biomarker to identify patients at risk of cancer transformation or relapse.


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