- Clinical pharmacology. // Clinical & Investigative Medicine;Aug97 Supplement, Vol. 20, pS9
Presents an abstract of the research manuscript `Alterations in cytokine production by the hydroxylamine metabolite of sulfamethoxazole,' by D.A. Hess and M.J. Rieder from the University of Western Ontario.
- Biodegradation studies of N-acetylsulfapyridine and N-acetylsulfamethazine in environmental water by applying mass spectrometry techniques. García-Galán, María; Frömel, Tobias; Müller, Jutta; Peschka, Manuela; Knepper, Thomas; Díaz-Cruz, Silvia; Barceló, Damiá // Analytical & Bioanalytical Chemistry;Jun2012, Vol. 402 Issue 9, p2885
This work evaluates the biodegradation of N-acetylsulfapyridine (AcSPY) and N-acetylsulfamethazine (AcSMZ), metabolites of two of the most commonly used sulfonamides (SAs) in human and veterinary medicine, respectively. Aerobic transformation in effluent wastewater was simulated using aerated...
- The chlorophyll-derived metabolite phytanic acid induces white adipocyte differentiation. Schluter, A.; Yubero, P.; Iglesias, R.; Giralt, M.; Villarroya, F. // International Journal of Obesity & Related Metabolic Disorders;Sep2002, Vol. 26 Issue 9, p1277
Phytanic acid is a derivative of the phytol side-chain of chlorophyll, it appears in humans following the ingestion of fatcontaining foods and is present in human blood at a low micromolar concentration. It may activate retinoid X receptors (RXR) or peroxisome proliferator-activated receptor...
- T cells: MAIT cells specific for microbial metabolites. Papatriantafyllou, Maria // Nature Reviews Immunology;Nov2012, Vol. 12 Issue 11, p743
The article discusses a research regarding the response of mucosal-associated invariant T (MAIT) cells to microbial metabolities that references the study "MR1 presents microbial vitamin B metabolites to MAIT cells," by L. Kjer-Nielsen and colleagues in the October 10, 2012 issue.
- Comparative Investigations of the Glucosinolate-Myrosinase System in Arabidopsis Suspension Cells and Hypocotyls. Sophie Alvarez; Yan He; Sixue Chen // Plant & Cell Physiology;Mar2008, Vol. 49 Issue 3, p324
Glucosinolates are secondary metabolites derived from amino acids. Upon hydrolysis by myrosinases, they produce a variety of biologically active compounds. In this study, the glucosinolateâ€“myrosinase system was characterized in Arabidopsis suspension cells. A total of seven glucosinolates...
- The Development of In Vitro Culture Methods to Characterize Primary T-Cell Responses to Drugs. Faulkner, Lee; Martinsson, Klara; Santoyo-Castelazo, Anahi; Cederbrant, Karin; Schuppe-Koistinen, Ina; Powell, Helen; Tugwood, Jonathan; Naisbitt, Dean J.; Park, B. Kevin // Toxicological Sciences;May2012, Vol. 127 Issue 1, p150
Editor's Highlight: This paper reports an in vitro cell culture system from human donors for the prediction of the allergic potential of drugs. Naive T cells were cultured in the presence of a drug and tested for transformation of the naive phenotype into a memory phenotype. These results...
- Metabolic cartography: experimental quantification of metabolic fluxes from isotopic labelling studies. O’Grady, John; Schwender, Jörg; Shachar-Hill, Yair; Morgan, John A. // Journal of Experimental Botany;Jun2012, Vol. 63 Issue 6, p2293
For the past decade, flux maps have provided researchers with an in-depth perspective on plant metabolism. As a rapidly developing field, significant headway has been made recently in computation, experimentation, and overall understanding of metabolic flux analysis. These advances are...
- Biological activity of ceramides and other sphingolipids. Stepulak, Michał; Leleń, Karolina; Malejczyk, Magdalena; Majewski, Sławomir; Arct, Jacek // Advances in Dermatology & Allergology / Postepy Dermatologii i A;2012, Vol. 29 Issue 3, p169
Sphingolipids are a large group of lipids which play a key role in the cellular life cycle. In addition to structural functions (they are constituents of cell membranes), they are known to be involved in processes of intercellular recognition and signal transmission. Ceramides, which are...
- SAICAR drives cancer cell survival. Zaromytidou, Alexia-Ileana // Nature Cell Biology;Jan2013, Vol. 15 Issue 1, p16
The article focuses on the importance of succinylaminoimidazolecarboxamide ribose5'-phosphate (SAICAR), a metabolite which stimulates pyruvate kinase isoform M2 (PKM2) crucial in the metabolic reprogramming of cancer cells towards growth and survival when glucose is scarce.