- Morphine's merits. // Wilson Quarterly;Spring90, Vol. 14 Issue 2, p133
Focuses on the effects of morphine. Addictive properties; Medial system; Tolerance level.
- A better way to block surgery pain. Franklin, Deborah; Fraser, Laura // Health (Time Inc. Health);Oct93, Vol. 7 Issue 6, p20
Presents the beneficial effects of giving morphine before surgery. Study by Catherine Richmond of London School of Medicine; Dosage and manner of administration; Significantly less painful recovery. INSET: Steps in the light direction..
- Teratogenic Effects of Alcohol on Brain and Behavior. Mattson, Sarah N.; Schoenfeld, Amy M.; Riley, Edward P. // Alcohol Research & Health;2001, Vol. 25 Issue 3, p185
Presents information on a study which analyzed the teratogenic effects of alcohol on fetal brain and behavior. Criteria for the diagnosis of fetal alcohol syndrome; Results from neuropsychological studies; Results from brain imaging studies.
- Morphine-induced long-term sensitization to the locomotor effects of morphine and amphetamine depends on the temporal pattern of the pretreatment regimen. Vanderschuren, L. J. M. J.; Tjon, Guno H. K.; Nestby, Patrizia; Mulder, Arie H.; Schoffelmeer, Anton N. M.; Vries, Taco J. De // Psychopharmacology;1997, Vol. 131 Issue 2, p115
Abstract The development of behavioural sensitization is thought to depend on the dose and temporal pattern of drug treatment. Previous studies have shown that two distinct morphine pretreatment regimens cause different long-term neuroadaptations in rat striatum. Therefore, in the present study...
- Role of morphine maintenance dose in the development of tolerance and its attenuation by an NMDA receptor antagonist. Allen, R. M.; Dykstra, L. A. // Psychopharmacology;2000, Vol. 148 Issue 1, p59
Abstract Rationale: Current research shows that Nmethyl-D-aspartate (NMDA) receptor antagonists attenuate the development of morphine tolerance in rodent antinociceptive assays. Objective: The purpose of this study was to determine the role of morphine maintenance dose in the attenuation of...
- Effect of gabapentin-like compounds on development and maintenance of morphine-induced conditioned place preference. Andrews, Nick; Loomis, Sally; Blake, Robert; Ferrigan, Leanne; Singh, Lakhbir; McKnight, Alexander T. // Psychopharmacology;2001, Vol. 157 Issue 4, p381
Rationale: Psychological dependence to the opioid analgesic morphine is attributable to the rewarding properties of the drug, and its evolution can be divided into two distinct phases: development and maintenance. Both phases can be studied using conditioned place preference (CPP). Objectives:...
- Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the... Matthes, Hans W.D.; Maldonado, Rafael // Nature;10/31/1996, Vol. 383 Issue 6603, p819
Presents a study which disrupts the mu-opioid-receptor gene in mice by homologous recombination. The finding that there are no overt behavioral abnormalities or major compensatory changes within the opioid system; Investigation of the behavioral effects of morphine; The conclusion that the...
- The attenuation of morphine-conditioned place preference following chronic mild stress is reversed by a CCK[sub B] receptor antagonist. Valverde, Olga; Smadja, Claire; Roques, Bernard P.; Maldonado, R. // Psychopharmacology;1997, Vol. 131 Issue 1, p79
Abstract Chronic exposure to mild unpredictable stress has been found to abolish the acquisition of preference for a distinctive environment paired with morphine, whereas morphine induced conditioning place preference in non-stressed rats. Chronic treatment for 21 days with the tricyclic...
- Fatal outcome with use of rectal morphine for postoperative pain control in an infant. Gourlay, G.K.; Boas, R.A. // BMJ: British Medical Journal (International Edition);3/21/92, Vol. 304 Issue 6829, p766
Reports the fatal outcome of rectal morphine on an infant after nephrectomy. Implication of the case to the administration of drugs to both adults and pediatric patients; Limitations in fixed dosing provided by suppositories; Staff education and clinical protocols for ensuring efficacy and...