- Respiratory medicine. // Clinical & Investigative Medicine;Aug97 Supplement, Vol. 20, pS100
Presents an abstract of the research manuscript `Investigation of latent adenovirus 5 infection in guinea pig lung,' by H. Behzad et al.
- Therapeutics: Controlled destruction. Novak, Kristine // Nature Reviews Cancer;Jun2002, Vol. 2 Issue 6, p402
Presents findings of a study on the potential of selectively replicating adenoviruses that target E2F activity as systemic antitumor agents, previously published in the periodical 'Cancer Cell' in 2002. Propagation of the viruses in cells with defects; Mechanism of action.
- A therapeutic role for viruses. Pyper, Wendy // Ecos;Jan-Mar2000, Issue 102, p36
Examines the potential of adenoviruses to improve the health and growth of livestock raised under intensive conditions. Gamma-inferon protein carried by the viruses that can stimulate an animal's immune system; Plans for producing vaccines from adenoviruses for a range of animal diseases;...
- Common cold a cancer cure? Berardelli, Phil // Insight on the News;01/20/97, Vol. 13 Issue 2, p43
Reports that American medical researchers are testing the possibility of using the common cold virus adenovirus as a cure for cancer. Relationship between an adenovirus gene and the human genetic protein p53 which prevents the division of defective cells; How an altered gene could disable p53...
- Immunomodulatory Gene Therapy With Interleukin 12 and 4-1BB Ligand: Long-Term Remission of Liver Metastases in a Mouse Model. Martinet, Olivier; Ermekova, Vanadyia // JNCI: Journal of the National Cancer Institute;06/07/2000, Vol. 92 Issue 11, p931
Presents a study which investigated the effects of adenovirus-mediated gene therapy on mice with hepatic metastases induced by colon cancer cells. Methodology; Results and discussion; Conclusion.
- Generating p53-specific cytotoxic T lymphocytes by recombinant adenoviral vector-based vaccination in mice, but not man. Kuball, J.; Schuler, M.; Antunes Ferreira, E.; Herr, W.; Neumann, M.; Obenauer-Kutner, L.; Westreich, L.; Huber, C.; Wölfel, T.; Theobald, M. // Gene Therapy;7/1/2002, Vol. 9 Issue 13, p833
Mutations and aberrant expression of the p53 tumor suppressor protein are the most frequent molecular alterations in human malignancy. Peptides derived from the wild-type (wt) p53 protein and presented by major histocompatibility complex (MHC) molecules for T lymphocyte recognition are believed...
- Tumour angiogenesis as a target for adenoviral mediated antisense gene therapy in human prostate cancer. Wood, C G // Prostate Cancer & Prostatic Diseases;2000 Supplement 1, Vol. 3 Issue 4, pS43
Presents information on the development of an adenoviral mediated gene therapy strategy that targets tumor cell production of factors important in the angiogenic cascade. Reduction in tumor cell production; Utilization of reverse transcriptase-polymerase chain reaction.
- Hide and seek. Le Page, Michael // New Scientist;04/28/2001, Vol. 170 Issue 2288, p11
Discusses the use of adenoviruses to sneak past the immune system and deliver missing genes to people with disorders. Process used to deliver genes; Problem with using adenoviruses for gene therapy; Result of using gene therapy to treat people with cystic fibrosis.
- Coacervate microspheres as carriers of recombinant adenoviruses. Kalyanasundaram, Subramanian; Feinstein, Sharon; Nicholson, Jennifer P; Leong, Kam W; Garver, Robert I // Cancer Gene Therapy;Mar1999, Vol. 6 Issue 2, p107
The therapeutic utility of recombinant adenoviruses (rAds) is limited in part by difficulties in directing the viruses to specific sites and by the requirement for bolus administration, both of which limit the efficiency of target tissue infection. As a first step toward overcoming these...