Respiratory medicine

August 1997
Clinical & Investigative Medicine;Aug97 Supplement, Vol. 20, pS98
Academic Journal
Presents an abstract of the research manuscript `Association of a deletion in the C-C chemokine receptor-5 gene with severe asthma,' by A.J. Sandford et al.


Related Articles

  • Inhibition of LPS-induced airway neutrophilic inflammation in healthy volunteers with an oral CXCR2 antagonist. Leaker, Brian R.; Barnes, Peter J.; O'Connor, Brian // Respiratory Research;Dec2013, Vol. 14 Issue 12, p1 

    Background: Inhaled lipopolysaccharide (LPS) induces a dose-dependent, acute neutrophilic response in the airways of healthy volunteers that can be quantified in induced sputum. Chemokines, such as CXCL1 and CXCL8, play an important role in neutrophilic inflammation in the lung through the...

  • A polymorphism in the CCL2 chemokine gene is associated with asthma risk: a case—control and a family study in Tunisia. Chelbi, H; Ghadiri, A; Lacheb, J; Ghandil, P; Hamzaoui, K; Hamzaoui, A; Combadiere, C // Genes & Immunity;Oct2008, Vol. 9 Issue 7, p575 

    Asthma is a complex genetic disorder characterized by chronic airway inflammation. We hypothesized that genetic polymorphisms in chemokines and their receptors alter leukocyte mobilization and may thus influence the risk and severity of childhood asthma. Distributions of the chemokine...

  • Growing up abolishes a genetic protection against asthma.  // Journal of Medical Genetics;Jan2004, Vol. 41 Issue 1, p17 

    Reports that researchers have found that the CCR5Δ32 mutation loses its protective effect against asthma as children mature. Possible explanation for conflicting results; Need for future association and linkage studies to take account of age as a confounder; Observation that the CCDRΔ32...

  • Blocking adenosine with antisense. Richardson, Peter J. // Nature;2/20/1997, Vol. 385 Issue 6618, p684 

    Provides background and analysis of a paper that confirms that adenosine is involved in an animal model of allergic asthma. The use of antisense oligodeoxynucleotides to reduce the number of adenosine A1 receptors in the lung; The potential therapeutic target for allergic asthma; The potential...

  • DNA antisense therapy for asthma in an animal model. Nyce, Jonathan W.; Metzger, W. James // Nature;2/20/1997, Vol. 385 Issue 6618, p721 

    Performs a randomized crossover study using the dust mite-conditioned allergic rabbit model of human asthma. The administration of an aerosolized phosphorotioate antisense oligodeoxynucleotide targeting the adenosine A1 receptor; The desensitization of the animals to a subsequent challenge...

  • Increased allergen-specific, steroid-sensitive gammadelta T cells in bronchoalveolar lavage fluid... Spinozzi, Fabrizio; Agea, Elisabetta // Annals of Internal Medicine;1/15/96, Vol. 124 Issue 2, p223 

    Examines whether allergen-specific, steroid-sensitive gamma delta T cells are increased in bronchoalveolar lavage fluid of patients with asthma. Macrophages as main cellular component in bronchoalveolar lavage fluid specimens obtained from normal patients; Role of T lymphocytes in the induction...

  • A genome-wide search for linkage to asthma phenotypes in the genetics of asthma international network families: evidence for a major susceptibility locus on chromosome 2p. Pillai, Sreekumar G.; Chiano, Mathias N.; White, Nicola J.; Speer, Marcy; Barnes, Kathleen C.; Carlsen, Karin; Gerritsen, Jorrit; Helms, Peter; Lenney, Warren; Silverman, Michael; Sly, Peter; Sundy, John; Tsanakas, John; von Berg, Andrea; Whyte, Moira; Varsani, Shela; Skelding, Paul; Hauser, Michael; Vance, Jeffery; Pericak-Vance, Margaret // European Journal of Human Genetics;Jun2007, Vol. 15 Issue 6, p714 

    A correction to the article "A genome-wide search for linkage to asthma phenotypes in the genetics of asthma international network families: evidence for a major susceptibility locus on chromosome 2p" that was published in the previous issue is presented.

  • Indication of linkage and genetic heterogeneity of asthma according to age at onset on chromosome 7q in 107 French EGEA families. Dizier, Marie-H�l�ne; Besse-Schmittler, C�line; Guilloud-Bataille, Michel; Selinger-Leneman, Hana; Kauffmann, Francine; Clerget-Darpoux, Fran�oise; Demenais, Florence // European Journal of Human Genetics;Nov2001, Vol. 9 Issue 11, p867 

    It is generally believed that an early age at the onset of disease is associated with a stronger genetic component. Our aim here was to investigate both linkage and genetic heterogeneity of asthma, the latter corresponding to different genotype relative risks of a putative linked gene according...

  • Gammadelta T cells in asthma. Rossman, Milton D.; Carding, Simon R. // Annals of Internal Medicine;1/15/96, Vol. 124 Issue 2, p266 

    Editorial. Comments on the role of gamma delta T cells in the development of asthma. Increased T cells in the bronchoalveolar fluid from patients with asthma; Secretion of various cytokines by T cells that are important for both cellular and humoral responses.


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics