Fertility preservation in cancer patients

Asefi, F.
June 2014
Iranian Journal of Reproductive Medicine;Jun2014 Supplement, Vol. 12, p125
Academic Journal
Introduction: Survival rates for childhood cancer have improved greatly during the past few decades. With increasing numbers of children cured, attention has focused on their quality of life. fertility preservation is now being recognized as an issue of great importance. Materials and Methods: In this review article, electronic searches were undertaken inPubMed, Scholar google and up to date since 2014. Results: The established means of preserving fertility include embryo cryopreservation, gonadal shielding during radiation therapy, ovarian transposition, conservative gynecologic surgery such as radical trachelectomy, donor embryos/oocytes, gestational surrogacy, and adoption. The experimental methods include oocyte cryopreservation, ovarian cryopreservation and transplantation, in vitro maturation, and ovarian suppressionin. In men the established means of preserving fertility include the use of assisted reproductive techniques (ART), cryopreserved sperm in the setting of very low numbers of stored sperm, intracytoplasmic sperm injection for men with poor sperm quality and experimental protocols, such as testicular tissue cryopreservation. Conclusion: With advances in methods for the preservation of fertility, providing information about risk of infertility and possible options of fertility preservation to all young patients with cancer, and discussing future fertility with them should be also considered as one of the important parts of consultation at the time of cancer diagnosis. Since the efficacy of ART is significantly reduced after chemotherapy, early referral for fertility preservation before gonadotoxic treatment will give these young women the best chance to conceive.


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