The role of Chlamydia trachomatis infection on seminal interleukins and semen parametrs in infected males of infertile couples from Iran

Marvast, L. Dehghan; Talebi, A. R.; Ghasemzadeh, J.; Pacey, A.
June 2014
Iranian Journal of Reproductive Medicine;Jun2014 Supplement, Vol. 12, p119
Academic Journal
Introduction: Chlamydia trachomatis stimulates both humoral and cell-mediated immune responses. Given the knowledge that infections may play a causative role in male infertility and male faetor is a cause of infertility in 50% of cases, the hypothesis that increasing interleukin levels in seminal plasma correlates negatively with semen parameters in infertile men was tested. Materials and Methods: The impact of C. trachomatis DNA and antibodies in the male partners of infertile couples and related this to semen FVU samples were examined for C. trachomatis DNA using PCR. Serum samples from 250 men were examined for serum C. trachomatis IgG and IgA and IgM using an immunotluorescence assay. Semen samples were examined for semen analysis & interleukins. Levels of ILs were determined by ELISA. Results: 45 men were positive for C. trachomatis IgG, 3 for IgM but none were positive for IgA. Concentration of semen leucocytes were correlated with levels of IL-6 (p=0.012). IL-8 levels were negatively eorrelated with semen volume (p=0.013) and positively correlated with male age (p=0.039) and concentration of seminal leucocytes (p=0.001). Semen PH and level of IL-6 was significantly higher in the IgG positive men (p=0.056; p=0.055) whereas semen volume was significantly lower (p=0.001). Conclusion: Seminal interleukin levels might be a sensitive and useful marker of silent infection/inflammation of the male genital tract. Since there is no correlation between male age and semen volume, reduced semen volume must be caused by accessory glands infection without damage to sperm or spermatogenesis.


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