TITLE

Nano-particle Titanium Dioxide (TiO2)-induced damages in mice testis correlates with enzymatic antioxidant line deficiency

AUTHOR(S)
Teyri, V.; Razi, M.; Farokhi, F.; Shafiee, S.
PUB. DATE
June 2014
SOURCE
Iranian Journal of Reproductive Medicine;Jun2014 Supplement, Vol. 12, p117
SOURCE TYPE
Academic Journal
DOC. TYPE
Abstract
ABSTRACT
Introduction: Nano-particle Titanium Dioxide (TiO2) is a non-combustible, odorless powder that is widely used for sunscreens and as coating for self-cleaning windows. There are several reports, which are indicating that TiO2 is able to exert cytotoxic impacts and induce lipid peroxidation and severe DNA damage. In present study we examined the dose effect of TiO2 on germinal cells apoptosis as well as its impact on enzymatic antioxidant status. Materials and Methods:Twenty four mature mice were randomly divided into four groups as control-sham (received 0.3mL normal saline, ip) and test groups including: low dose (10 mg/kg, ip), medium dose (50 mg/kg, ip) and high dose (100mg/kg, ip)-TiO2-received groups. After 35 days, the tissue levels of glutathione peroxidase (GSH-px), super oxide dismutase (SOD), and catalase (CTS), the serum level of testosterone and Leydig cells steroidogenic foci were evaluated. Germinal cells apoptosis was estimated using TUNEL staining. Results: TiO2 significantly (p<0.05) decreased GSHpx, SOD and catalase levels of the testicles in a dose dependent manner. Epi-fiuorescent analyses showed that the intracytoplasmic steroid content of the Leydig cells decreased in TiO2-received animals and developed depending on dose. In a same pattern, the serum level of testosterone decreased and percentage of tubules with apoptotic cells enhanced depending on dose. Conclusion: Our data suggest that, TiO2 exerts its pathological impact via down-regulating antioxidant status, which in turn is able to adversely impact the endocrine status. Ultimately defected antioxidant capacity associated with damaged endocrine status provokes the apoptosis in germinal cells.
ACCESSION #
96841779

 

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