TITLE

Celecoxib and silymarin attenuated varicocele-induced damages at testicular and sperm levels; evidence for endocrine and antioxidant statuses

AUTHOR(S)
Mazhari, S.; Razi, M.; Malekinejad, H.; Sadrkhanlou, R.
PUB. DATE
June 2014
SOURCE
Iranian Journal of Reproductive Medicine;Jun2014 Supplement, Vol. 12, p117
SOURCE TYPE
Academic Journal
DOC. TYPE
Abstract
ABSTRACT
Introduction: Varicocele (VCL) results in considerable disorders in male reproductive potential. Varicocele exerts its impact via enhancing infiammation and downregulating testicular endocrine and antioxidant statuses. Celecoxib (CCB) is a non-steroidal anti-infiammatory drug (NSAID), which is used as cyclooxygenase-2 (COX-2) inhibitor. Silymarin (SMN) is a fiavonoid complex, which is known for its antioxidant potenfial. Present study was designed for evaluating the protective effect of CCB and SMN on VCL-induced damages in testicles and sperm cells. Materials and Methods: VCL was induced in 24 mature male rats and then animals were randomly divided into four groups including; non-treated VCL induced, CCB-treated (10mg/kg, orally), SMN-treated (100mg/kg, orally), SMN+CCB-treated groups. Following 60 days after VCL induction, spermatogenesis ratio evaluated by assessing tubular differentiation (TDI), repopulation (RI) indexes. Leydig cells steroid foci were evaluated by using epifiuorescent staining. Immune eels infiltration, tissue total antioxidant capacity (TAC) and malondialdehyde (MDA) content as well as sperm count, motility, abnormality and DNA damage were analyzed. Results: CCB and SMN co-administration elevated VCL-reduced TDI, RI and SPI and reduced immune cells infiltrafion. The Leydig cells steroidogenic foci increased in CCB+SMN, SMN and CCB-treated groups, respecfively. SMN+CCB significantly (p<0.05) upregulated VCL-reduced TAC and reduced tissue MDA. All treated animals exhibited remarkably (p<0.05) higher sperm count, sperm motility, viability and reduced sperm abnormality and DNA damage. However it was more pronounced in SMN+CCB-treated group. Conclusion: Our data suggest that, SMN inhibited the VCL-induced damages via up-regulating antioxidant status and CCB limited the disorders by attenuating VCL-induced inflammation.
ACCESSION #
96841778

 

Related Articles

  • ANTIOXIDANT THERAPY IN MALE INFERTILITY TREATMENT. Vinogradov, I. V.; Afanasyeva, L. M.; Gabliya, M. Y.; Alexeev, R. A. // Reproductive BioMedicine Online (Reproductive Healthcare Limited;Oct2010 S3 Supplemen, Vol. 20, pS35 

    Introduction: Varicocele occurs in 7-10% of all post-pubertal males; it is associated with 30- 40% of the cases of male infertility. Between 2008 and 2010, we observed 198 patients (age >35 y.o.) with embryos derived from their spermatozoa ceasing development on Days 3-5 after ICSI, who were...

  • Varicocelectomy Significantly Decreases Oxidative Damage in Sperm DNA.  // Fertility Weekly;2/25/2008, p7 

    The article provides information about the role of varicocelectomy in sperm deoxyribonucleic acid (DNA) with oxidative damage. According to the researchers from Taiwan, subfertile men who underwent varicocelectomy experience significant decreases in oxidative damage in sperm DNA. Furthermore,...

  • Testosterone and vitamin E administration up-regulated varicocele-reduced Hsp70-2 protein expression and ameliorated biochemical alterations. Khosravanian, Narges; Razi, Mazdak; Farokhi, Farah; Khosravanian, Hajar // Journal of Assisted Reproduction & Genetics;Mar2014, Vol. 31 Issue 3, p341 

    Purpose: This study was designed to evaluate the protective effects of vitamin E (VitE) and testosterone on varicocele (VCL)-induced damage in testis and sperm parameters and their effects on Hsp70-2 chaperone expression and on antioxidant status. Methods: Wistar rats were divided into five...

  • Pregnancy rates drop when varicoceles go untreated. Snider, Tim // Urology Times;10/1/2004, Vol. 32 Issue 14, p14 

    Presents a study on the link of pregnancy rates following varicocelectomy to the length of time a patient is infertile. Comparison of motile sperm counts and pregnancy rates; Benefits from varicocelectomy; Diagnosis of varicocele in infertile patients.

  • Effect of Varicocele Grade and Age on Seminal Parameters. Vivas-Acevedo, Giovanny; Lozano, Jesús Ricardo; Camejo, María Isabel // Urologia Internationalis;Sep2010, Vol. 85 Issue 2, p194 

    Aim: To evaluate the effect of presence, grade and anatomical side of varicocele on semen parameters and to identify age-related modifications in semen quality in men with varicocele. Methods: A prospective clinical study was performed in 363 men with varicocele and 155 normozoospermic men...

  • Surgical Repair Increases Testicular Volume.  // Fertility Weekly;5/19/2008, p9 

    The article presents the study conducted by the researchers regarding the use of varicocele surgical repair in improving left testicular volume and semen parameters of men in Japan. The researchers have administered the study to 44 men with clinical left varicocele using Doppler imaging and...

  • Modulation of Cytosolic Calcium Levels Differs in Men and Semen Parameters. Arienti, Giuseppe // Fertility Weekly;2/20/2006, p10 

    The article cites a study a study which found out that the cytosolic calcium levels in the spermatozoa are modulated differently in men with and without varicocele. Progesterone and nitric acid play a significant roles in the activation of spermatozoa. Spermatozoa from patients with varicocele...

  • Infertility: A Guy Thing. Ehrenfeld, Temma // Newsweek (Pacific Edition);3/25/2002 (Pacific Edition), Vol. 139 Issue 12, p53 

    Focuses on the causes and treatment options for male infertility. Details of problems, including sperm that swim poorly; Role of a large cluster of veins in the scrotum called a varicocele in causing male infertility; Story of Patrick Jermyn who had surgery for a varicose vein to treat his...

  • Varicocele treatment: A 2-centers comparison between non microsurgical open correction, laparoscopic approach and retrograde percutaneous sclerotization on 463 cases. Ollandini, Giangiacomo; Liguori, Giovanni; Ziaran, Stanislav; Málek, Tomáš; Mazzon, Giorgio; Concilio, Bernardino de; Bucci, Stefano; Benvenuto, Sara; Belgrano, Emanuele; Trombetta, Carlo // Archivio Italiano di Urologia, Andrologia: Organo Ufficiale di S;Sep2013, Vol. 85 Issue 3, p143 

    Objectives: To determine whether there are differences in sperm parameters improvement after different varicocele correction techniques. To determine the role of age in sperm parameters improvement. Methods: 2 different European centers collected pre- and postoperative sperm parameters of...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics