Stereological Study of the Effect of Green tea (Camellia sinensis) Hydroalcholic Extract on Glomeruli Components in Mice Exposed to Sodium arsenite

Shahmohammadi, R.; Sharlatzadeh, M.; Mehranjani, M. Soleimani; Momeni, H.; Noreini, S. Naderi
June 2014
Iranian Journal of Reproductive Medicine;Jun2014 Supplement, Vol. 12, p116
Academic Journal
Introduction: Sodium arsenite as an environmental pollutant has adverse effects on various body organs. The aim of this study was to investigate the protective effect of green tea extract (GTE) on glomeruli and its components, as well as Serum creatinine and blood urea nitrogen (BUN in the mice following exposure to sodium arsenite. Materials and Methods: Adult male NMRI mice (30±5 g) were randomly divided into 4 groups (n=6), control, GTE (100mg/kg/day), Sodium arsenite (5mg/kg/day) and Sodium arsenite +GTE, and treated for 34 days. At the end of treatment period, mice were killed and their left kidneys were taken out, flxed, sectioned, processed and stained using Heidenhain& azan method. The Glomeroli and its components, as well as serum samples were analyzed. Data were astatically analyzed using one way ANOVA and Tukey's test and the means difference was considered signiflcant at p<0.05. Results: A significant reduction in the volume of glomeroli and tuft, and the serum creatinine (p<0.001) and BUN (p<0.04) significantly increased in the Sodium arsenite group when compared to the other groups. The mentioned parameters were normalized in the sodium arsenite + GTE group to the control mice. Conclusion: Our results showed that green tea could compensate the adverse effects of sodium arsenite on the mice renal tissue; therefore addition of green teato the daily diet of people in industrial cities could protect them from adverse effects of environmental pollutants like arsenic.


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