TITLE

Toxic effects of Carthamus tinctorius L. (Safflower) extract on mouse spermatogenesis

AUTHOR(S)
Mohamadpour, M.; Mirhoseini, M.; Khorsandi, L.
PUB. DATE
June 2014
SOURCE
Iranian Journal of Reproductive Medicine;Jun2014 Supplement, Vol. 12, p116
SOURCE TYPE
Academic Journal
DOC. TYPE
Abstract
ABSTRACT
Introduction: To evaluate the effects of aqueous extract of Carthamus tinctorius L., also named safflower, on mouse spermatogenesis. Materials and Methods: Sixteen adult male NMRI mice were used. Experimental group received Carthamus tinctorius L. extract at the dose of 200 mg/kg for 35 consecutive days and control group received only distilled water. Testicular histopathology, morphometric analysis and spermatogenesis assessments were performed for evaluation of the Carthamus tinctorius L. extract effects on testis. Results: Histopathological criteria such as epithelial vacuolization, sloughing of germ and detachment were signiflcantly decreased in Carthamus tinctorius L. treated mice (p<0.001). Carthamus tinctorius L. extract induced formation of multinucleated giant cells in the germinal epithelium. Carthamus tinctorius L. exfract also caused a signiflcant decrease in seminiferous tubule diameter, seminiferous epithelium height and maturation arrest (p<0.001). Conclusion: Carthamus tinctorius L. extract has toxic effects on mouse testicular tissue, and recommended to use it with caution if there is a reproductive problem.
ACCESSION #
96841775

 

Related Articles

  • Does the Testicular Apoptotic Index Vary with Serum Gonadotropins and Testicular Histopathology in Infertile Men? Kandirali, Engin; Cayan, Selahittin; Armagan, Abdullah; Erol, Bulent; Kadioglu, Ates // Urologia Internationalis;Oct2009, Vol. 83 Issue 3, p349 

    Aims: Testicular apoptosis has been shown in human specimens, but its correlation with serum gonadotropins and testosterone levels has not been studied. The aim of this study was to evaluate the relationship of apoptosis with serum hormone levels and testicular histopathological findings in...

  • Inheritance and linkage analyses of menadione reductase, phosphoglucoisomerase, and... Carapetian, J.; Estilai, A. // Journal of Heredity;Nov/Dec95, Vol. 86 Issue 6, p480 

    Examines the inheritance and linkage analyses of menadione reductase, phosphoglucoisomerase and triosephosphate isomerase in safflower. Genetic markers of safflower; Safflower types and cultivars; Performance of horizontal starch gel electrophoresis in seedlings.

  • Herbicide combinations for postemergent weed control in safflower (Carthamus tinctorius) Derksen, Douglas A.; Blackshaw, Robert E.; Muendel, H.-Henning Muendel // Weed Technology;Jan/Mar1990, Vol. 4 Issue 1, p97 

    No abstract available.

  • Effects of diethylhexyl phthalate (DEHP) given neonatally on spermatogenesis of mice. Zhang, Xi-Feng; Zhang, Teng; Wang, Liu; Zhang, Hong-Ying; Chen, Yong-De; Qin, Xun-Si; Feng, Yan-Min; Feng, Yan-Ni; Shen, Wei; Li, Lan // Molecular Biology Reports;Nov2013, Vol. 40 Issue 11, p6509 

    We previously demonstrated that the effects of diethylhexyl phthalate (DEHP) alter reproduction function on male mice. Immature male mice were treated daily with DEHP from postnatal day 7-21, 7-35, 7-49, in a dose-dependent manner. As results, both the quality and quantity of spermatozoa were...

  • Toxic effects of Carthamus tinctorius L. (Safflower) extract on mouse spermatogenesis. Mirhoseini, Mehri; Mohamadpour, Masoomeh; Khorsandi, Layasadat // Journal of Assisted Reproduction & Genetics;May2012, Vol. 29 Issue 5, p457 

    Objective: To evaluate the effects of aqueous extract of Carthamus tinctorius L., also named safflower, on mouse spermatogenesis. Methods: Sixteen adult male NMRI mice were used. Experimental group received Carthamus tinctorius L. extract at the dose of 200 mg/kg for 35 consecutive days and...

  • Chronic Addiction to Tramadol and Withdrawal Effect on the Spermatogenesis and Testicular Tissues in Adult Male Albino Rats. Ibrahim, Marwan Abdel-Latif; Salah-Eldin, Alaa-Eldin // Pharmacology;Apr2019, Vol. 103 Issue 3/4, p202 

    Aim: The present study aimed to elucidate the effects of tramadol on the testicular functions of adult male rats due to the chronic usage of tramadol and the effect of its withdrawal. Method: Adult male albino rats were classified into the following 3 groups: (I) a control administered with...

  • Incidence of AZF (azoospermia factor) deletions and familial forms of infertility among patients... Selva, J.; Kanafani, S.; Prigent, Y.; Poncet, V.; Bergere, M. // Journal of Assisted Reproduction & Genetics;Nov97, Vol. 14 Issue 10, p593 

    Provides information on a study conducted to determine the incidence of spermatogenesis (AZF) deletions among patients requiring intracytoplasmic sperm injection. Details on investigations carried out on the familial forms of infertility suggesting autosomal mutations; Methodology used in...

  • Safflower offered as option to chemical summer fallow. Griekspoor, P. J. // Kansas Farmer (0022-8583);Mar2012, Vol. 150 Issue 3, p16 

    The article discusses the alternative use of safflower as a crop to chemical summer fallow.

  • safflower:. Schlegel, Rolf H. J. // Encyclopedic Dictionary of Plant Breeding & Related Subjects;2003, p485 

    An encyclopedia entry for safflower is presented.

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics