The detrimental effects of zinc oxide nanoparticles on mouse spermatogenesis

Talebi, A. R.; Moridian, M.; Khorsandi, L.
June 2014
Iranian Journal of Reproductive Medicine;Jun2014 Supplement, Vol. 12, p114
Academic Journal
OBJECTIVE: To evaluate the effects of zinc oxide nanoparticles on mouse spermatogenesis. METHODS: Thirty two adult male NMRI mice were used. Experimental Groups (ZNP-1-ZNP-3) received one of the following treatments daily for 35 days: 5, 50 and 300 mg/kg zinc oxide nanoparticles respectively. Control group received only distilled water. Epididymal sperm parameters, testicular histopathology, morphometric analysis and spermatogenesis assessments were performed for evaluation of the zinc oxide nanoparticles effects on testis. RESULTS: Epididymal sperm parameters including sperm number, motility and percentage of abnormality were significantly changed in 50 and 300 mg/kg zinc oxide nanoparticles treated mice (p?


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