TITLE

Oxytocin can decrease apoptotic index in testis under acute ischemic-reperfusion in a rat model

AUTHOR(S)
Ghasemnezhad, R.; Mohammadghasemi, F.; Faghani, M.; Bahadori, M.; Etebary, S.; Yari, N.
PUB. DATE
June 2014
SOURCE
Iranian Journal of Reproductive Medicine;Jun2014 Supplement, Vol. 12, p114
SOURCE TYPE
Academic Journal
DOC. TYPE
Abstract
ABSTRACT
Introduction: The aim of this study was to investigate this hypothesis that oxytocin can decrease apoptotic index in testis under acute ischemia reperfusion in a rat model. Materials and Methods: Twenty adult rats were randomly divided into 4 groups: 1: eontrols 2: Ischemia- Reperfusion (IR) 3: oxytocin (OT) 4: oxytocin after induction of IR (OTA). Testicular ischemia was achieved by torsion of the left testis 720 clockwise for 2 hours. Two hours after isehemia, torsion was removed and reperftision was performed. Immediately after induction of reperfusion 0.03 μg/kg oxytocin were administered intraperitoneally to the OTA group. Three hours after surgery left testis were removed and evaluations were made by Jhonson's score, Radioimmunoassay (RIA), immunohistochemistry and histomorphometry for study of maturity of spermatogenesis, endocrine profiles, apoptosis and quantitative studies, respectively. Results: Induction of ischemia-reperftision in group2 induced marked degeneration of germ eells, edema and blood vessels congestion in testis. A significant reduced Jhonson's score were detected in IR group in compare with eontrols (p<0.05).and apoptotic index increase significantly (p<0.05) in compare with the controls. Sex hormones were not changed in all experimental groups. Administration of OT in OTA group decrease the apoptotic index in compare with the IR group significantly (p<0.05) and histological parameters same as germinal epithelium thickness and gem cells number were increased but not significant statically. Conclusion: These results suggested that oxytocin can decrease apoptotie index and improves complication of acute isehemic reperfusion in testis in a rat model.
ACCESSION #
96841770

 

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