The effect of grape seed hydroalcholic extract on testosterone concentration in fluoxetine induced oxidative stress in the mouse testise

Hajizadeh, Z.; Soleimani, M.; Najafi, B.; Zarei, L.
June 2014
Iranian Journal of Reproductive Medicine;Jun2014 Supplement, Vol. 12, p110
Academic Journal
Introduction: The selective serotonin reuptake inhibitors (SSRI), including fluoxetine (FLX) are used for the treatment of depression and psychiatric disorders such as panic disorder and anxiety. Grape seed extract (GS extract) is a natural extract from the seed of grape that is rich in mono-, oligo- and poly- meric polyphenols and anthocyanins, flavonoids, GS extract involves in ameliorating the oxidative stress in vitro and in vivo.The aim of present study was to evaluate the protective effect of Grape seed extract on Fluoxetineinduced testosterone level, TCA and malondialdehyde (MDA) production in mice. Materials and Methods: In this study 24 mature male mice were used. The animals divided into four groups as, control, FLX (20mg/kg), FLX (20mg/kg) + BGSE (100mg/kg) and BGSE (100 mg/kg) orally for 42 days. Lipid peroxidation levels were measured using the method ofbased on the degree malondialdehyde (MDA) production. Result:The results showed that in FLX group percentage of Tissue antioxidant capacity and Semm testosterone significantly (p<0,05) reduced in comparison with the control, GSE and FLX+GSE groups while in FLX group percentage of the tissue MDA increased significantly (p<0.05) in comparison with the control, GSE and FLX-i-GSE groups. Conclusion: Fluoxetine can induce male infertility. Simultaneously administration FLX and GSE prevent negative effect of FLX on testise.


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