A histopathologic study of the ameriorating effect of grape seed hydroalcholic extract against Fluoxetine toxicosis in male mice

Hajizadeh, Z.; Najafi, G.; Soleimani, M.; Shariatzadeh, M.; Zarei, L.
June 2014
Iranian Journal of Reproductive Medicine;Jun2014 Supplement, Vol. 12, p109
Academic Journal
Introduction: Fluoxetine (FLX) is a selective serotonin reuptake inhibitors antidepressant. FLX affects chemicals in the brain that may become unbalanced and cause depression, panic, anxiety, or obsessive-compulsive symptoms. Grape seed extract (GSE) antioxidants neutralize free radicals and oxidative stress. Therefore this study was designed to investigate Protective effect of GSE hydroalcholic extract against fluoxetine- induced damage on testicular. Materials and Methods: To follow up present study 24 mature male mice were used. The animals divided into four groups as, control, FLX (20 mg/kg), FLX (20 mg/kg)+ GSE (100 mg/kg) and GSE (100 mg/kg) orally for 42 days. After the last gavage, animals were sacriflced. Histopathological analysis of the testis was carried out. Repopulation index (RI), Tubular differentiation index (TDI), Spermiogenesis index (SPI), Mitotic index (MI), Sertoli cell index (SCI) was measured using a microscope. Results: Histological results showed that the male mice exposed to fluoxetine had significantly (p<0.05) reduction in TDI, SPI, MI, SCI and RI. However, Grape seed extract could reduce all negative impacts of fluxetine. Conclusion: Fluoxetine can induce male infertility. Simultaneously administration FLX and GSE prevent negative effect of FLX on testise.


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