Antifertility effect of hydro-alcoholic extract of Fennel (Foeniculum vulgare Mill) seed in male rats

Kooti, W.; Mansori, E.; Ghasemiboroon, M.; Hasanzadeh Noohi, Z.; Asadi-Samani, M.; Azimi Resketi, M.; Foroutan Rad, M.
June 2014
Iranian Journal of Reproductive Medicine;Jun2014 Supplement, Vol. 12, p107
Academic Journal
Introduction: Skyrocketing population is one of the main problems in modern communities. Today, study of anti-fertility effects of herbs has been considered because of the side effects of chemical medicines.This study is aimed to investigate the antifertility effect of chronically administered of foeniculim vulgare mill seed extract in male rats. Materials and Methods: In this experimental study, 40 Wistar rats divided into five groups of eight rats each. The control group received distilled water and the experimental groups were orally administrated 1ml fennel extract in four doses of 25, 70, 140, and 280 mg/kg/B.W daily for sixty days. After the last gavage, rat'sanesthetized; caudal parts of the right epididymis were used for sperm counting. After fixation of testis, tissue sections were prepared and studied microscopically for the evaluation of morphometric and histological changes. The data were analyzed by oneway ANOVA test using SPSS 15 software. Results: The number of spermatogonia and Sertoli cells decreased significantly in doses of 140 and 280 mg/kg compared with the control group (P<0.05). The number of primary spermatocyte and sperm count decreased significantly in the experimental groups when compared to control group (P<0.05). Furthermore Thickening of the basement membrane, cell apoptosis and irregular arrangement of germinal epithelium were observed in the experimental groups compared to the control group. Conclusion: Hydro-alcoholic extract of fennel seed in used doses could reduce reproductive activity in male rats and has anti fertility activity.


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