The effect of hydro-alcoholic extract of Apium Graveolens in female rats on fertility, the weight and sex ratio of rat offspring

Kooti, W.; Ghasemiboroon, M.; Ahangarpoor, A.; Amirzargar, A.; Resketi, M. Azimi; Rad, M. Foroutan; Hardani, A.
June 2014
Iranian Journal of Reproductive Medicine;Jun2014 Supplement, Vol. 12, p107
Academic Journal
Introduction: Infertility is one of the most common problems that observed in approximately 15% of couples. Apium Grave/ens (celery) is a medicinal plant with antioxidant properties and rich of flavonoid. This study was conducted to evaluate the effect of hydro-alcoholic extract of celery in female rats on fertility, weight and sex ratio of rat off spring. Materials and Methods: In this experimental study,30 female rats were divided randomly into 3 groups. The control group received 1ml of distilled water, and experimental groups received respectively doses of 100 and 200 mg/kg/BW celery extract for five weeks by gavage. During the fifth week, two female rats from each group was mated with one healthy male rat. After a week, every female rat was kept in the separate cages. Females received celery extract during pregnancy and until childbirth. Finally, the number of the delivery females, number, weight and sex ratio of offspring were recorded. The data were analyzed using SPSS 15 software and ANOVA test. Results: There was no significant difference in delivery rate and newborns sex ratio between the experimental and control groups (p>0.05). The number of newborns was significantly increased in each experimental group compared to the control group (p≤0.05). Also a significance decrease was observed in the weight of offspring in each experimental group compared to the control group (p≤0.05). Conclusion: Celery due to antioxidant property improves the fertility and increase the number of offspring but decrease weight of offspring. Thus use of medicinal plants in the diet should be more considered.


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