Infertility in couple and celecoxib usage (an experimental design)

Jahanpour, N.
June 2014
Iranian Journal of Reproductive Medicine;Jun2014 Supplement, Vol. 12, p105
Academic Journal
Introduction: Researches showed that infertility effect may be seen in some patients that used celecoxib for a long time. Celecoxib is a form of non-steroidal antiinflammatory drug (NSAID) that directly targets COX-2, an enzyme responsible for inflammation and pain. The goal of this survey is assess the effect of celecoxib on reproductive system functions. Materials and Methods: In This experimental survey we study on the effect of celecoxib on rat reproductive system, on spermatogenesis and the level of blood testosterone hormone. Histological studies and measuring of weight (testis, prostate, seminal vesicle and epidydimis) and the level of blood testestron are done. 50 rats with 200-230 gr. weight selected and compared in 5 groups. Control group (no drug given), case group (solvent drug: Di- methyl sulfoxide), 3 cases group (orally celecoxib 10, 20 and 40mg/kg given daily) for 15 days. In the end of 15 days heart blood sampling for measuring serum testosterone level accomplished after that reproductive systems separated and prepared for histological study. Results: Result showed Sertoli cells in control and case groups are differences. So that in case group (40mg/kg) number of Sertoli cells decreased due to decrease testestron level. This can cause production of abnormal sperms. Significant differences are seen in the mean weight of prostate per body weight in case group (40 mg/kg) in compared with control group. Conclusion: High doses of celecoxib can produce infertility.


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