TITLE

Association assessment of ESRa gene polymorphism (rs9340799) with endometriosis risk in Iranian's women population

AUTHOR(S)
Asadi, R.; nejad, P. Mohammady; Safarpour, M; Abolghasemi, S; Abbaspour, M; Ebrahimi, A.
PUB. DATE
June 2014
SOURCE
Iranian Journal of Reproductive Medicine;Jun2014 Supplement, Vol. 12, p105
SOURCE TYPE
Academic Journal
DOC. TYPE
Abstract
ABSTRACT
Endometriosis is a gynecoligical disorder that defined by the presence of endometrial tissue outside the uterus. Clinical manifestations range dysmenorreal chronic pelvc pain, dyspareunia, dysphasia and infertility to ompletely asymptomatic disease. Epidemiology studies reveal thet endometriosis affects more than 10% of reproductive age women and possibly causes infertility. Endometriosis is a multiactorial disease and interplay between environmental factors and genetic variations. Estrogen receptor alpha (ESR-a) is a nuclear receptor protein encoded by the gene ESR-a which is significantly associated with endometriosis. We aimed to evaluate 100 women affected with endometriosis for ESR-a selected SNP including rs9340799 by ARMs-PCR.As a result we confirmed thet there is no a significant association between rs9340799 and endometriosis.
ACCESSION #
96841748

 

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