TITLE

Effect of Ferula assa-foetida oleo gum resin on spermatic parameters and testicular histopathology in male Wistar rats

AUTHOR(S)
Mirjalili, A.; Bagheri, S.; Yadegari, M.; Anvari, M.; Porentezari, M.; Dashti, M.
PUB. DATE
June 2014
SOURCE
Iranian Journal of Reproductive Medicine;Jun2014 Supplement, Vol. 12, p104
SOURCE TYPE
Academic Journal
DOC. TYPE
Abstract
ABSTRACT
Introduction: Asafoetida has been used asaphrodisiac agent in different countries. The present study was aimed to evaluate the effectiveness of asafoetida on spermatic and testicular parameters in treatment rats. Materials and Methods: 30 male Wistar rats received 25, 50,100 and 200 mg/kg asafoetida respectively. After six weeks, a small part of the cauda epididymis of each rat was dissected and the spermatic parameters were evaluated for at least 200 spermatozoa of each animal. Testes of all rats were harvested for pathologic examination. The testosterone concentration of serum was also determined. Results: This study indicated that asafoetida significantly increased the number and viability of sperms (p<0.05). Histological study showed that spermatogenesis process and number of Leydig cells was increased with increasing the dose, but the Leydig cells become vacuolated. Johnsen score in experimental groups was increased compare to control although this difference was not significant (p>0.05). Conclusion: In conclusion, asafoetida showed a positive effect on spermatic parameters although the histopathological effects on the testes were observed, particularly at high doses.
ACCESSION #
96841746

 

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