TITLE

Comparison the effect of Levonorgestrel IUD (Mirena) with oral medroxyprogesterone acetate and Letrozole on abnormal uterine bleeding with simple endometrial hyperplasia

AUTHOR(S)
Karimi-Zarchi, M.; Ghane-Ezabadi, M.
PUB. DATE
June 2014
SOURCE
Iranian Journal of Reproductive Medicine;Jun2014 Supplement, Vol. 12, p104
SOURCE TYPE
Academic Journal
DOC. TYPE
Abstract
ABSTRACT
Introduction: The aim of this study was to compare the effect of levonorgestrel IUD with oral medroxy progesterone acetate and Letrozole on abnormal uterine bleeding with simple endometrial hyperplasia. Materials and Methods: Forty five patients referred to Shahid Sadoughi gynecology clinics from 2009 until 2011 who suffered fromabnormal vaginal bleeding or endometrial thickness were enrolled. The patients were divided into3 groupsrandomly.First group (n=20) received 2.5 mg Letrozol daily for 3 months, the second group (n=42) received 10 mg MPA for 10 days a month for 3 months and the third groupincluding 20 patients with IUD levonorgestrel (Mirena) which releases 20 meg levonorgestrel per day. At end of 3rd month, the endometrium thickness was measured by sonography was measured and the pathology of endometrial sampling were compared. Results: Age range of patients was between 22-47 years. The endometrial thicknesses decreased in allthree groups. The mean endometrial thicknesses after teartment in MPA, Letrozole and Mirena groups were (16.09±7.37), (9.97±4.03) and (7.4±2.41) retrospectively. Pathology results in all three groups showed no significant differences (p=0.06). Conclusion: Levonorgestrel IUD (Mirena) in comparison with Medroxyprogesterone and Letrozole is more effective in treatment of AUB and simple endometrial hyperplasia. It also had significantly less completions for patients. Although response to treatment. Although response to treatment was shown in all these three methods.
ACCESSION #
96841745

 

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