Effect of vitamin E with or without folic acid on oxidative stress in uterus of induced diabetic rats with streptozotocine

Mahdian, Z.; Zal, F.; Mostafavipoor, Z.
June 2014
Iranian Journal of Reproductive Medicine;Jun2014 Supplement, Vol. 12, p104
Academic Journal
Introduction: Studies show that infertility is on the rise and some diseases such as diabetes mellitus play a key role in this. Chronic hyperglycemia and metabolic disorders caused by diabetes mellitus increases the production of free radicals in the body and will ultimately lead to oxidative stress in tissues. The amount of tissue oxidative damage in diabetic patients has a direct effect on fertility trends. This study is designed to investigate the antioxidant effect on oxidative stress rate in uterus of diabetic rat. Materials and Methods: Diabetic female rats with streptozotocin were divided into control, diabetic groups & diabetic Treated groups. Treated groups received folic acid and vitamin E Via gavage for 4 weeks. Antioxidant markers: Level of enzyme activities GR, GPX and CAT and Protein levels of MDA, GSH were measured in uterine tissue. Results: The results of this study showed that the activity of enzyme GPX, at the diabetic groups were decreased compared with control group and its activity at treated groups was increased compared with diabetic groups. In addition, levels of MDA protein at the diabetic group had increased than controls group, whereas its level in the diabetic group was reduced compared to treated groups. The results were analyzed statistically and the difference between them was significant. Conclusion: Vitamin E by restoring the activity of antioxidant markers is responsible an important protective role against oxidative damage caused by diabetes. In this way, the use of antioxidants can have a positive effect on diabetes-related infertility.


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