The effect of Glutathione on the stereological parameters of hypothalamus in Cyclophosphamide- treated mice

Ghalavandi, M.; Bahmanpour, S.; Namavar, M.
June 2014
Iranian Journal of Reproductive Medicine;Jun2014 Supplement, Vol. 12, p103
Academic Journal
Introduction: New anti-cancer drugs have increased survival and fertility in young patients. One of the most important side effects of these drugs (such as cyclophosphamide) is on gonadal system and hypothalamus. These changes will cause premature menopause and infertility. Cyclophosphamide therapy for autoimmune diseases and cancers causes an unacceptably high incidence of negative changes in hypothalamus. One of possible chemical for reducing these side effects is thiol (such as glutathione). This study was performed to evaluate the capability of glutathione for reducing the cyclosphosphamide effects on the hypothalamus using stereological methods. Materials and Methods: Sixty female mice were randomly assigned into five groups: All groups including control group had free access to water and food. The sham and gluthathion (Glu) groups received normal saline and gluthathione (10mmol/day), respectively daily by gavage for 16 days while cyclophosphamide group (Cyc) received only cyclophosphamide (50mg/kg;i.p) as a single dose and fifth (Cyc+Glu) group received both gluthathione and cyclophosphamide. The number of neuron and the volume of hypothalamus were evealuated using stereological methods. Results: The number of neuron and the volume of hypothalamus significantly decreased in cyclophosphamide group in comparison with control, gluthathione and Cyc+Glu groups (p<0.05). Conclusion: The present study showed that Thiol improved structural changes of hypothalamic caused by cyclophosphamide in mice, suggesting that using Thiol accompanying chemotherapy drugs may have protection effects on fertility.


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