Poly cystic ovarian syndrome induces ovarian oxidative stress

Tahmasebi, F.; Movahedin, M.; Mazaheri, Z.
June 2014
Iranian Journal of Reproductive Medicine;Jun2014 Supplement, Vol. 12, p102
Academic Journal
Introduction: Polycystic ovarian syndrome as a prevalent disease in women should be considered. This disease is due to an increase in the number of cysts in the ovaries and balance of oxidant and antioxidant can be affected by that. Therefore, this study is an attempt to investigate oxidative stress level in cystic ovarian tissue of mouse model. Methods and Methods: In this study, 10 NMRI female mice were divided into 2 groups: control and experimental (PCOS that was induced using single injection of estradiol valerate; 40 mg/kg). During 8 weeks after PCOS induction, body weight was measured weekly. Mice in each group were scarified and their ovarian tissue was collected. To confirm the model, histopathological study was down. Oxidative stress was measured in ovarian tissue by using DCFH-DA and fiowcytometric assay. Data was analyzed by T-test. Results: The results showed that there is a significant increasing level (p<0.05) of gaining weight in experimental group compared to control group. Ovarian tissue histopathological study was demonstrated PCO model after passing two months of induction. Fiowcytometric data reveled that oxidative stress increased in ovarian tissue of PCO group. Conclusion: The results of this study express that PCO can lead to increase oxidative stress in ovarian tissue. This increase can lead to a feedback and make more cysts in ovarian tissue of patient.


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