TITLE

Hawthorn berries ethanolic extract lowered polycystic ovarian syndrome-elevated testosterone level and improved the altered ovaries structure

AUTHOR(S)
Alijanpour, K.; Malekinejad, H.; Razi, M
PUB. DATE
June 2014
SOURCE
Iranian Journal of Reproductive Medicine;Jun2014 Supplement, Vol. 12, p102
SOURCE TYPE
Academic Journal
DOC. TYPE
Abstract
ABSTRACT
Introduction: Polycystic ovarian syndrome (PCOS) is the most common endocrinopathy seen in women. Hawthorn extract is traditionally used for treating cardiovascular diseases and plasma cholesterol lowering. Various constituents including flavonoids with biological activities including free radical scavenging, anti-lipoperoxidation and anti-inflammatory have been isolated from hawthorn. Due to crucial role of inflammation and high cholesterol in the etiology of PCOS, we aimed to study the hawthorn's berries hydroalcoholic extract potential effects on estradiol valerate-induced PCOS in rats. Materials and Methods: PCOS was induced in 3 groups of rats (n=6) by intramuscular injection of estradiol valerate (EV, 4 mg/rat in 0.2 ml sesame oil). The control group only received the vehicle (0.2 ml sesame oil). A 60-day interval was chosen to let the cysts become established. Following the interval time, effects of hawthorn berries extract (HBE, 100 mg/kg, orally) and oral contraceptive pills (OCP, containing 60 mg/kg estradiol, orally) on serum level of testosterone and the architecture of ovary via histological examinations were studied for 4 weeks. Results: Hormonal assay showed that EV injection resulted in 4 fold increase in serum level of testosterone, which both HBE and OCP significantly (p<0.05) lowered the PCOS-increased level of testosterone. 28 days HBE and OCP administration remarkably lowered the PCOS-induced cystic and atrectic follicles and increased the normal and functional follicles. Conclusion: Our data suggest that HBE could be a good candidate for further studies about its pure therapeutic agent (s), which might alone or in combination with other remedies be used to prevent or treat the PCOS.
ACCESSION #
96841739

 

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