The effects of 70% ethanolic extract of celery (Apium graveolens) on serum testosterone and gonadotropin levels in male rats

Kooti, W.; Ghasemiboroon, M.; Ghafourian Boroujerdnia, M.; Hasanzadeh Noohi, Z.; Faridi, S.; Foroutan Rad, M.; Azimi Resketi, M.
June 2014
Iranian Journal of Reproductive Medicine;Jun2014 Supplement, Vol. 12, p101
Academic Journal
Introduction: The importance of fertility and procreation as a factor for survival of the human race is not hidden from anyone. Celery has a plenty of nutritional and pharmaceutical applications. The presence of phytoestrogenic compounds has been reported in this plant. These compounds may affect the pituitary-gonad axis. The aim of the present study was to evaluate the effect of ethanolic extract of celery on serum testosterone and gonadotropin levels in male rats. Materials and Methods: In this experimental study, 32 male Wistar rats were divided into four groups of eight rats. The control group didn't receive any treatment. The placebo group received normal saline and the case groups received 200 and 300mg/kg/B.W of ethanolic extract of celery for 20consecutive days by oral administration. One day after the last gavage, animals anaesthetized and blood sampling from their heart was carried out. Then serum levels of testosterone, LH and FSH were measured by using ELISA method. Results: The level of LH in the case group receiving 200mg/kg of celery extract showed a significant decrease compared with the control and placebo groups (p<0.05). The level of FSH and testosterone in case groups didn't show any significant difference in comparison with the control group (p>0.05). Conclusion: The results indicated that administration 200 mg/kg doses of celery extract causes a significant reduction in serum LH Concentration, but it has no effect on ganadotropin and testosterone hormone in highest dose used in this study that was probably due to presence of flavonoid and antioxidant proporties of celery.


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