Effects of doxorubicin on reproductive system in animal model

Heidari, M.
June 2014
Iranian Journal of Reproductive Medicine;Jun2014 Supplement, Vol. 12, p101
Academic Journal
Introduction: Doxorubicin is a chemotherapeutic agent that used for the treatment some leukemias and Hodgkin's lymphoma, bladder, stomach, lung, and others. The aim of this study was to investigate the effect of cytotoxic events in the reproductive system caused by a single dose of doxorubicin. Materials and Methods: In this experimental study 30 male wistar rats were selected and randomly divided into two groups. Experiment groups were received 2.5 mg/kg and control groups just received normal saline for 60 days. Results: Results showed that doxorubicine had destructive effects on testis tissue and spermatogenesis in test group compared to control group within 60 days after administration, significant decrease in the weight of reproductive organs as compared to control animals. The sperm motility and count in cauda epidydimides, testicular ducts were significantly decreased. Spermatogenesis was decrease at primary and secondary spermatocyte stages and then diameter of seminiferous tubules, thickness of interstitial tissue, and thickness of testicular capsule, were studied. Diameter of seminiferous tubules and thickness of epithelium of seminiferous tubules significantly decreased, but thickness of interstitial tissue and thickness of testicular significant increased compared to controls (p<0.05). Conclusion: Generally doxorubicine administration causes decline in spermatogenesis and significant changes in diameter of seminiferous tubules, thickness of interstitial tissue, and thickness of testicular capsule in rat testis tissue. These changes may via the reducing of cell divide and toxic effects of doxorubicine.


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