TITLE

Evaluation of the protective effect of Nigella sativa oil on testicular tissue in mice following exposure to para-nonylphenol

AUTHOR(S)
Keikha, L.; Shariatzadeh, M. A.; Noreini, S. Naderi
PUB. DATE
June 2014
SOURCE
Iranian Journal of Reproductive Medicine;Jun2014 Supplement, Vol. 12, p99
SOURCE TYPE
Academic Journal
DOC. TYPE
Abstract
ABSTRACT
Introduction: Para-nonylphenol (p-NP) as an environmental pollutant exerts it's effects through endocrine disruption and inducing of oxidative stress in the male reproductive system. The aim was to investigate the protective effect of Nigella sativa oil (NSO) on testicular tissue in mice exposed to p-NP. Materials and Methods: Adult male NMRI mice with mean body weight 32±3g were divided into 4groups (n=6): control, NSO (5ml/kg/day), p-NP (250mg/kg/day) and p-NP+NSO. After oral treatment for 34 days, body and left testis weight were recorded and testis used for histopathological observations. The serum malondialdehyde (MDA) levels as a marker of lipid peroxidation was measured by spectrophotometry. Data were analyzed with One Way ANOVA and p<0.05 was considered significant. Results: In the testes of mice treated with p-NP, germinal epithelium was vacuolated and atrophy of the seminiferous tubules was observed. On this group a significant decrease in diameter of seminiferous tubules and germinal epithelium thickness and significant increase in the diameter of the seminiferous tubules lumen and MDA levels (p<0.001) was found compared to the other groups. Above parameters was significantly compensated in p-NP+NSO group. Body and testis weight and diameter of the nucleus of spermatogonia showed no significant change between groups (p>0.05). Conclusion: Our data indicates thatNSO as an antioxidant could compensate the pathological changes induced by p-NP on testicular tissuein adult mice. Therefore, addition of NSO to the daily diet can be a good strategy to reduce free radicals and improve the reproductive system of men that exposed to environmental pollutants.
ACCESSION #
96841733

 

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