TITLE

The protective role of Nigella Sativa oil on mice testicular tissue and spermatogenic cell populations following exposure to para-nonylphenol: A stereological analysis

AUTHOR(S)
Solati, A.; Soleimani Mehranjani, M.; Shariatzadeh, M; Naderi Noreini, S.
PUB. DATE
June 2014
SOURCE
Iranian Journal of Reproductive Medicine;Jun2014 Supplement, Vol. 12, p99
SOURCE TYPE
Academic Journal
DOC. TYPE
Abstract
ABSTRACT
Introduction: Nonylphenol as an environmental contaminant has adverse effects on male reproductive system. The aim was investigate the possible protective effect of Nigella sativa oil (NSO) on mice testicular tissue damage fallowing exposure to para-Nonylphenol (P-NP). Materials and Methods: Adult male NMRI mice (30±5 g) were divided into 4 groups (n=6), control, NSO (5mg/kg/day), p-NP (250mg/kg/day) and p-NP + NSO, and treated orally for 34 days. Finally, mice were sacrificed, their right testis were taken out, fixed, sectioned, processed and stained using heiden hain azan method. Total volume of testis and the total number of spermatogonia, spermatocyte, long and round spermatid and Sertoli cells were estimated stereologically. Lipid peroxidation index, malondialdehyde (MDA) level, was also measured.Data were statistically analyzed using one way ANOVA and means difference was considered significant at p<0.05. Results: There was a significant decrease intotal number of long and round spermatids, spermatocytes, spermatogonia and Sertoli cells as well as a significant increase in MDA level in p-NP group when compared to control ones (pO.OOl). The mentioned parameters were normalized to the control level in p-NP + NSO group. A significant decrease of MDA level was also found in NSO group in comparing with control group (pO.OOl). Conclusion: Our results rewealed that NSO could reduce the oxidative stress toxicity induced by Para-Nonylphenol in the testicular tissue and spermatogenic cells, suggesting that consumption of NSO, as an antioxidant, can prevent the side effects of p-NP exposure in industrial cities.
ACCESSION #
96841732

 

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