TITLE

Ameliorative effects of Curcumin on the spermatogenic cell populations in mice following exposure to sodium arsenite: A stereological study

AUTHOR(S)
Hatamikia, N.; Soleimani Mehranjani, M.; Mahmodi, M.; Naderi Noreini, S.
PUB. DATE
June 2014
SOURCE
Iranian Journal of Reproductive Medicine;Jun2014 Supplement, Vol. 12, p98
SOURCE TYPE
Academic Journal
DOC. TYPE
Abstract
ABSTRACT
Introduction: Sodium arsenite is a well know toxicant which suppresses spermatogenesis. The aim was to investigate the effect of curcumin, as a powerful antioxidant, on the spermatogenic cell populations in mice exposed to sodium arsenite. Materials and Methods: Adult male NMRI mice were divided into 4 groups (n=6): control, curcumin (15 mg/kg/day), sodium arsenite (5 mg/kg/day), sodium arsenite + curcumin. After oral treatment for 34 days, the right testis was removed, fixed, sectioned and stained using heiden hain azan method. The testis volume and weight, number of spermatogonia, spermatocytes, and spermatid and Sertoli cells were stereologically estimated. Data were analyzed using one-way ANOVA and Tuckey's test, the means difference was considered significant at p<0.05. Results: The number of spermatocytes and spermatids significantly reduced in mice treated with sodium arsenite compared to the control (pO.OOl). The mentioned parameters increased significantly in the sodium arsenite+curcumin group to the control level. The testis weight and volume, the total number of spermatogonia and Sertoli cells did not show any significant difference in the sodium arsenite group in comparison to the control ones (p>0.05). Conclusion: Our data indicates that curcumin may ameliorate the adverse effects of sodium arsenite on the spermatogenic cell population, therefore addition of curcumin to the daily diet of workers of industrial environments, who are exposed to arsenic, could prevent its adverse effects. Further studies are still required to confirm the above.
ACCESSION #
96841730

 

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