TITLE

Histopathological study of the effect of green tea extract on testicular damage induced by sodium arsenite in NMRI mice

AUTHOR(S)
Mohammadi, M.; Shariatzadeh, M.; Naderi Noreini, S.
PUB. DATE
June 2014
SOURCE
Iranian Journal of Reproductive Medicine;Jun2014 Supplement, Vol. 12, p97
SOURCE TYPE
Academic Journal
DOC. TYPE
Abstract
ABSTRACT
Introduction: Sodium arsenite is an environmental pollutant with ability to generate free radicals and tissue damage. The aim of this study was to investigate the effect of green tea extract (GTE), as an antioxidant, on structure and tissue of testis in mice treated with sodium arsenite. Materialsand Methods: Adult male NMRI mice with mean body weight 30±5g were randomly divided into 4 groups (n=6): control, sodium arsenite (5mg/kg/day), GTE (100mg/kg/day) and sodium arsenite+GTE. Oral treatments were performed till 34 days. After the treatment, the left testis was removed, weighed and was used for histopathological observation. The serum malondialdehyde (MDA) levels were used as an indirect index of lipid peroxidation and were determined by spectrophotometric method. Data were analyzed with One Way ANOVA and means difference was considered significant at (p<0.05). Results: Testes of sodium arsenite-treated mice showed vacuolation and atrophy of seminiferous tubules. Inthis group, a significant decrease in mean diameter of seminiferous tubules, germinal epithelium thickness (p<0.001) and a significant increase inthe mean diameter of seminiferous tubules lumen and MDA levels (p<0.001) were found compared to the control group. In Sodium arsenite+ GTE group, GTE could significantly compensate the harmful effects of Sodium arsenite on the above parameters compared to the sodium arsenite group (p0.001. Sodium arsenite had no effect on the body and testis weight and diameter of spermatogonial nucleus (p>0.05). Conclusion: The result indicates that green tea extract may be useful in reducing the toxic effects induced by sodium arsenite in mice testis.
ACCESSION #
96841727

 

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