The decreased level of antioxidant and increased oxidative stress in Iranian women with polycystic ovary syndrome (PCOS)

Mod, M.; Lahazi, V.; Naderi, Z.
June 2014
Iranian Journal of Reproductive Medicine;Jun2014 Supplement, Vol. 12, p97
Academic Journal
Introduction: Polycystic ovary syndrome (PCOS) is a common disorder of infertility which affects more than 100 million women. It is characterized by chronic anovulation, hyperandrogenism and obesity. PCOS is also associated with oxidative stress changes. Here, we aimed to investigate the level of antioxidants and oxidative stress in Iranian women with PCOS for the first time. Materials and Methods: In this study 30 women with PCOS and 30 healthy women were included. C-reactive protein (CRP), insulin, AOPP and level of total antioxidants status (TAOS) were measured from blood samples. Results: The levels of insulin, CRP, AOPP and protein carbonyl were significantly increased in women with PCOS compared with healthy women but there was a decrease in level of TAOS in PCOS women. Conclusion: These changes show that oxidative stress contributes to PCOS and the decrease of antioxidants leads to increase of oxidation products contributing to PCOS.


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