Effect of Urtica dioica extract on stereological structure of ductus epididymis in streptozotocin induced diabetic rats

Hamidian, Gh.; Zangisheh, M.
June 2014
Iranian Journal of Reproductive Medicine;Jun2014 Supplement, Vol. 12, p95
Academic Journal
Introduction: Diabetes mellitus is a common metabolic disorder that can be associated with many complications in epididymis. Epididymis plays an essential role in the motility acquisition and fertilizing capacity of spermatozoa and its significant impairment can be a factor in male infertility. This study was carried out to investigate the effects of ethanolic extract of U. dioica on structure of epididymis in diabetic rats by stereological techniques. Materials and Methods: Fifteen adult male wistar rats were divided into control, diabetic and treatment groups. Hyperglycemia was induced by 50 mg/kg Streptozotocin (STZ). One week after STZ injection, treatment group received 30 mg/kg/day U. dioica extract by oral gavage for 30 consecutive days. Finally animals were euthanized and whole of right epididymis was removed, weighted and fixed in 10% neutral buffered formalin. Using isotropic uniform random samples and standard tissue processing, the height and volume of epithelium, lumen diameter and tunica muscularis thickness were estimated by unbiased stereological techniques in different region of epididymis. Results: This study showed that diabetes could lead to structural changes in all regions of epididymis. Stereological results indicated that height and volume of epithelium and tunica muscularis thickness were significantly reduced in diabetic rats and U. dioica could inhibit these changes strongly especially in caudal regions (p<0.01). It was also revealed that lumen diameter was significantly increased in diabetic rats but there is no significant differences between treated and control group. Conclusion: Administration of ethanolic extract of U. dioica can prevent diabetic undesirable side effects on epididymis.


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