The study of levofloxacin effects on ovary tissue and follicle count in rat

Eyrisofla, N. Vahidi; Far, M. Ahmadi; Golmakani, M. Rabiee; Eini, A. Mohammad
June 2014
Iranian Journal of Reproductive Medicine;Jun2014 Supplement, Vol. 12, p94
Academic Journal
Introduction: Today one of the societies difficulties is ovary tissue damage and thereinafter infertility symptom. Levofloxacin is one of the antibiotics whit usages of the wide therapeutic that often use for genitourinary and lower respiratory systems infections. Target of this study is determination of Histopathology and Cytotoxic of Levofloxacin effects on ovary tissue of rat. Materials and Methods: In this study we used, female Wistar rats weighting 250±20 g and 8 weeks old that grouped in 4 groups. Along the study the control group was without treatment and the other groups fed with levofloxacin in 200, 500 and 750 ml doses daily. After 22 days, rats became unconscious with ether and the logged ovary's tissues was referred to pathology laboratory for take slides and histopathology study. Results: The result showed that Levofloxacin cause increase primordial follicles, decrease primary follicles, decrease secondary follicles and oocytes destructions. With increasing dose of this drug, observed more destructive effects in ovary tissue. Conclusion: According to changes which made in this study, it is possible to the cytotoxic effects of levofloxacin in ovary tissue. We do attention to this drug effects which decrease the follicles and decrease the amount of fertility in humans.


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