TITLE

Effect of Nitroglycerin treatment on the number of pups in female rats

AUTHOR(S)
Rajabi, S.; Zal, F.; Mostafavi-Pour, Z.
PUB. DATE
June 2014
SOURCE
Iranian Journal of Reproductive Medicine;Jun2014 Supplement, Vol. 12, p93
SOURCE TYPE
Academic Journal
DOC. TYPE
Abstract
ABSTRACT
Introduction: High levels of reactive oxygen species (ROS) and reactive nitrogen species (RNS) in the uterus lead to oxidative stress which can decrease expression of adhesion molecules and may cause impaired blastocyst implantation. Nitroglycerin (NTG), source of ROS and RNS, is a nitrate drug, effective in lowering blood pressure and chest pain in patients with angina pectoris and congestive heart failure. In this study we aimed to investigate the long and short term effects of nitroglycerin treatment on the pups number. Materials and Methods: The rats (150-200g) in long-term test group were administered with NTG (15mg/kg) and normal saline (1 ml/kg) in controls for 4 weeks. Afterwards, they mated and their treatment continued until the end of pregnancy and finally their pups were counted. In short-term groups, treatments of the rats were started after mating similar to what have been done for the long term treatment groups. Results: In long-term NTG treated group the pups number decreased compared to the controls (p<0.05). In short-term NTG treated group the number of pups had no difference with control group. Conclusion: Our investigations indicated that the long-term NTG treatment may down regulate adhesion molecules which have important role in the implantation and this may lead to decrease in the pups number. But the short-term NTG treatment may not have adverse effects on the adhesion molecules expression, implantation and the number of pups.
ACCESSION #
96841714

 

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