Effect of prenatal methamphetamine administration during gestational days in mice

Khoradmehr, A.; Anvari, M.; Mirjalili, F.; Golzadea, J.; Sabour, M.
June 2014
Iranian Journal of Reproductive Medicine;Jun2014 Supplement, Vol. 12, p90
Academic Journal
Introduction: Recently, administration of methamphetamine (MA) has been increased in pregnant women. MA crosses through the placenta and effect on fetal. In the present study, the effect of prenatal exposure of 10 mg/kg/day of MA was evaluated in pregnant mice on Crown-rump length, placenta circumference, body and placenta weight gain of fetus and histological changes evaluated in fetus in each group and then compared to others. Materials and Methods: Twenty-four NMRI pregnant mice were divided into four groups. First, second and third groups were injected intraperitoneally 10 mg/kg/lday MA from gestational day (GD)1 to GD7, GD7 to GDI4 and GDI to GDI4, respectively. Forth group, as control group, was injected saline from GDI to GD14. On GD14, the pregnant females were killed and fetuses and placenta were weighted and then crown-rump length of fetus was measured with caliper. For Histological evaluation fetuses stained with hematoxyline-eosin and TUNEL assay was applied to assess cell apoptosis. Results: Fetus body weight showed significantly decreased in third group compared to first and second groups, and lower crown-rump length in Fetuses observed between third group and others (p⩽0.001). Fetus in MA treated showed lower placenta circumference compared to control. Histological changes such as Exencephaly, cleft palate, hemorrhage and immature fetus found in second and third groups. Apoptotic cells were observed in second and third groups but there were no significant increased compared to others. Conclusion: In utero administration of MA can cause morphological and histological changes in mice fetus but the exact mechanism remains unclear.


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