Investigation of KDR gene polymorphisms (-604, 1719 and 1192) in women with unexplained recurrent pregnancy loss in comparison with normal women

Honarvar, N.; Ghasemi, N.; Sheikhha, M. H.; Farashahi-, E.; Yazd
June 2014
Iranian Journal of Reproductive Medicine;Jun2014 Supplement, Vol. 12, p89
Academic Journal
Introduction: Recurrent pregnancy loss is the most important fertility problem which affects about 1-5% of pregnant women. One of the possible genetic causes of unknown recurrent pregnancy loss is impairment in angiogenesis system and one of the most important genes is Kinas insert-Domain-Receptor (KDR). It is found on vasculogenic and angiogenic precursor cells in human placenta. Determining the association between single nucleotide polymorphisms (SNPS) (-604, 1719 and 1192) of KDR gene in women with unexplained Recurrent pregnancy loss in comparison with healthy women. Materials and Methods: In this study 110 women with history of recurrent pregnancy loss in the reproductive age as case and 120 healthy women with no history of abortion and at least one healthy child are chosen as control group. Genotyping of these polymorphisms were analyzed using the Amplification Refractory Mutation System-Polymerase Chain Reaction (ARMS-PCR) technique. Results: Genotype frequencies of SNP -604 in women with unexplained recurrent pregnancy loss were as follows TT (26.4%) TC (45.5%) and CC (28.2%) while in normal group genotypes were 30%, 43.4% and 26.7%respectively. Genotypes AA, AT and TT of SNP(1719) presented frequencies of 30%, 2.8%and 67.3% respectively in case group and 3.4%, 32.5% and 64.2% in controls. Distribution of Genotypes in SNP 1192 was 79.1%, 19% and 1.8% for GG, AG and AA in case and 80%, 20% and 0% in the same order in controls . Conclusion: Results of this study demonstrated no association between recurrent pregnancy loss and -604, 1719 and 1192 SNPS of KDR genes.


Related Articles

  • Hormonal treatment of male infertility: FSH. Foresta, C.; Selice, R.; Ferlin, A.; Arslan, P.; Garolla, A. // Reproductive BioMedicine Online (Reproductive Healthcare Limited;Dec2007, Vol. 15 Issue 6, p666 

    FSH plays a crucial role in spermatogenesis. In the fetal and neonatal development stages, FSH activates the proliferation of the Sertoli cells and successively, during the pubertal phase, it influences the mitotic activity of the spermatogonia and encourages cellular differentiation, until...

  • Association between a PD-1 gene polymorphism and antisperm antibody-related infertility in Iranian men. Zamani, Mohammad; Asbagh, Firouzeh; Massoud, Amir; Salmaninejad, Arash; Massoud, Ahmad; Rezaei, Nima // Journal of Assisted Reproduction & Genetics;Jan2015, Vol. 32 Issue 1, p103 

    Objective: Programmed cell death-1 (PD-1, Pdcd1), an immunoreceptor belonging to the CD28/CTLA-4 family negatively regulates antigen receptor signalling by recruiting protein tyrosine phosphatase, SHP-2 upon interacting with either of two ligands, PD-L1 or PD-L2. This study investigates PD-1...

  • Genetic predictors of controlled ovarian hyperstimulation: where do we stand today? Altmäe, S.; Hovatta, O.; Stavreus-Evers, A.; Salumets, A. // Human Reproduction Update;Nov2011, Vol. 17 Issue 6, p813 

    BACKGROUND Nowadays, the use of IVF has improved the prospects of infertility treatment. The expected outcome of IVF depends greatly on the effectiveness of controlled ovarian hyperstimulation (COH), where exogenous gonadotrophins are used to induce folliculogenesis. The response to stimulation...

  • Correlation with TNF-α Gene Polymorphism.  // Fertility Weekly;1/27/2014, p7 

    The article discusses the study "Tumor necrosis factor-α gene polymorphism relationship to seminal variables in infertile men," by Zalata and colleagues, published in the 2013 issue of the journal "Ultraviolet" (Uv). It assesses the relationship between tumor necrosis factor (TNF)-α...

  • Impact of Cystic Fibrosis Transmembrane Regulator (CFTR) gene mutations on male infertility. Elia, Jlenia; Mazzilli, Rossella; Delfino, Michele; Piane, Maria; Bozzao, Cristina; Spinosa, Vincenzo; Chessa, Luciana; Mazzilli, Fernando // Archivio Italiano di Urologia, Andrologia: Organo Ufficiale di S;2014, Vol. 86 Issue 3, p171 

    Objective. The aim of this study was to evaluate the prevalence of most common mutations and intron 8 5T (IVS8-5T) polymorphism of CFTR gene in Italian: a) azoospermic males; b) non azoospermic subjects, male partners of infertile couples enrolled in assisted reproductive technology (ART)...

  • Genetic variants in Piwi-interacting RNA pathway genes confer susceptibility to spermatogenic failure in a Chinese population. Gu, Aihua; Ji, Guixiang; Shi, Xiangguo; Long, Yan; Xia, Yankai; Song, Ling; Wang, Shoulin; Wang, Xinru // Human Reproduction;Dec2010, Vol. 25 Issue 12, p2955 

    BACKGROUND The Piwi subfamily of genes is involved in spermatogenesis for the maintenance and meiosis of germline stem cells. Mice bearing targeted mutations in Piwi genes (Miwi, Mili and Miwi2) are sterile with distinct defects in spermatogenesis. We hypothesized that Piwi gene polymorphisms...

  • Association of Follicle-Stimulating Hormone Receptor Polymorphisms with Ovarian Response in Chinese Women: A Prospective Clinical Study. Yan, Yuanliang; Gong, Zhicheng; Zhang, Lu; Li, Yanping; Li, Xiong; Zhu, Lin; Sun, Lunquan // PLoS ONE;Oct2013, Vol. 8 Issue 10, p1 

    Background:Follicular stimulating hormone (FSH) is a glycoprotein and widely used for the treatment of infertility; FSH action is mediated by FSH receptor (FSHR), SNPs of which determine the ovarian response. Two polymorphisms of the FSHR gene were identified, which caused a change of threonine...

  • Placental Lesions and Abnormal Neurocognitive Function at School Age in Extremely Low--Birth Weight Infants. Zanardo, Vincenzo; Franzoi, Malida; Vedovato, Stefania; Trevisanuto, Daniele; Suppiej, Agnese; Chiarelli, Silvia // Pediatric & Developmental Pathology;Mar/Apr2008, Vol. 11 Issue 2, p164 

    A letter to the editor is presented placental lesions as predictors of neuromotor and cognitive outcome at school age in extremely low birth weight infants (ELBWI).

  • An interesting pathological specimen at delivery. Mathew, Roshen; Devi, K. S. Shakuntala; Rao, Ganesh; Thomas, Sheju // BMJ: British Medical Journal (International Edition);11/15/2008, Vol. 337 Issue 7679, p1177 

    The article presents a picture quiz regarding a pathological specimen obtained after the delivery of a baby.


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics