Effect of the MDRl gene C1236T polymorphism in male infertility in Guilan

Tajbakhsh, F.; Mashayekhi, F.; Hamidi Madani, A.; Bahadori, M.
June 2014
Iranian Journal of Reproductive Medicine;Jun2014 Supplement, Vol. 12, p87
Academic Journal
Introduction: Infertility is a common problem affecting one in six couples. P-glycoprotein (P-gp), a product of the MDR1 (ABCB1) gene, may be a link between genetic and environmental factors contributing to the development of male infertility because pesticides (P-gp substrates) are well established factors of male infertility. MDR1 (ABCB1) is member of the family of ATP binding cassette (ABC) transporter. It is plasma membrane transporter that is expressed in various organs. In the present study are examined the possible association of C1236T: rsl 128503 functional ABCB1 polymorphism with response to male infertility. Materials and Methods: In total, 35 male patients undergoing semen analysis due to initial infertility workup were included in the study. The control group consisted of 65 healthy males with proven fertility. MDR1 3435C>T genotyping was performed by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Results: The significant association between MDR1 gene polymorphism and male infertility was not observed (p=0.06). Conclusion: Infertility can occur due to idiopathic factors. Studies show that polymorphisms in several genes implicated in male infertility. Concludes that polymorphism 1236C>T MDR1 gene may be one factor contributing to male infertility. Research on the effect of these genes is still being investigated.


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