Oocyte cryopreservation, advantages and disadvantages

Malekpour, A.; Shirazi, A.; Heidari, B.; Borjian, S.; Saravari, A.; Behzadi, B.
June 2014
Iranian Journal of Reproductive Medicine;Jun2014 Supplement, Vol. 12, p83
Academic Journal
Oocyte cryopreservation has practical and ethical advantages compared with embryo storage. It allows oocytes to be quarantined before donation, simplifies the management of a donation programme, and ensures the most efficient distribution of the few donated oocytes available. Women at risk of early ovarian failure can store oocytes so that they can retain the possibility of bearing their own genetic children. Oocyte cryopreservation is vital for women without a partner and eliminates the problems associated with withdrawal of consent when embryos are stored. More contentiously, women could store oocytes to delay childbearing without there being a medical indication. During routine assisted conception cycles, oocytes can be cryopreserved as an emergency procedure or to avoid producing supernumerary embryos. In human, vitrification is a promising approach to oocyte storage which can conserve oocyte competence Viable pregnancies have been conceived from the embryos derived from vitrified oocytes, but to date there have been too few live births to allow a realistic assessment of the efficiency of oocyte vitrification. A number of outstanding issues regarding methodology, dramatic difference (s) in its physio-structural properties, safety of storage and the long-term health of the children born via this approach as notable topics will be resolved only as oocyte vitrification becomes more widespread designed to provide the evidence base required in modern assisted conception. It is vital that procedures do not become 'set in stone' before they are fully optimised and that protocols and outcomes, especially live births, are fully documented and published.


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