TITLE

Protective effect of green tea ovary function and LH and FSH level in mice treated with anti cancer drug Paclitaxel

AUTHOR(S)
Asoudeh, E.
PUB. DATE
June 2014
SOURCE
Iranian Journal of Reproductive Medicine;Jun2014 Supplement, Vol. 12, p82
SOURCE TYPE
Academic Journal
DOC. TYPE
Abstract
ABSTRACT
Introduction: Paclitaxel is an anticancer drug commonly used to treat ovarian cancer. Its destructive effects on ovary have been proved by several researches. The anticancer, antioxidant and chemoprotective effects of green tea may protect ovary from destructive effects of Paclitaxel. Materials and Methods: In this study effects of 2 doses (200, 300 mg/kg/bw) of green tea extract on the levels of LH and FSH hormones in Paclitaxel treated mice were investigated. 35 NMRI adult female mice (8weeks) were divided into 7 groups as follows: Groupl: control; Group 2: saline (sham); Group 3: case 1 (IP injection of 0.2 mg/kg paclitaxel for 3 days); Group 4, 5: case 2, 3 (IP injection of 200, 300mg/kg/bw green tea extract respectively); Group 6, 7: experimental 1, 2 (IP injections of paclitaxel+green tea extract). Blood serums of different group were collected one week after the last injection. Data were analyzed buy ANOVA and p<0.05 was considered as significant. Results: Results showed that LH hormone in the group sham 1 decreased in comparison with group control, and groups sham 2, 3 were significantly increased compared to group sham 1, and the second experimental group was significantly higher than the group sham 1. Hormones FSH in the group sham 1. Significantly increased compared to control, and only group sham3 was significantly reduced compared to group shaml. FSH in experimental group 1, 2 were significantly lower than in group sham 1. Conclusion: Results show that high doses of green tea extract can hormone level LH, FSH closer control group.
ACCESSION #
96841684

 

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